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Table 3 Predictors of mortality in CTD-ILD

From: Demographic and clinical predictors of progression and mortality in connective tissue disease-associated interstitial lung disease: a retrospective cohort study

Variable

Unadjusted analysis

Multivariable analysis

Hazard ratio

p

Hazard ratio

p

(95% CI)

(95% CI)

Age per 10y increase

1.03 (1.01, 1.05)

< 0.001

1.0 (1.0, 1.1)

0.002

Male vs. female

1.8 (1.1, 3.0)

0.03

2.5 (1.2, 4.9)

0.010

Ethnicity

 Caucasian vs. non-Caucasian

2.1 (1.1, 3.9)

0.03

1.4 (0.6, 3.4)

0.51

 EA vs. non-EA

0.7 (0.3, 1.7)

0.48

0.5 (0.1, 1.4)

0.17

 SA vs. non-SA

0.9 (0.3, 2.4)

0.81

1.1 (0.3, 3.9)

0.94

 FN vs. non-FN

3.2 (1.3, 7.5)

0.009

4.7 (1.3, 16.4)

0.02

Pos. vs. neg. Smoking

1.2 (0.8, 1.9)

0.32

1.1 (0.6, 1.9)

0.85

Income per 10 K increase

1.0 (0.9, 1.1)

0.53

1.0 (0.9, 1.1)

0.71

CTD subtype

 SSc vs. RA

2.6 (1.1, 6.2)

0.04

10.4 (1.6, 67.1)

0.014

 SSc vs. MCTD

2.2 (0.7, 7.1)

0.17

1.1 (0.3, 4.3)

0.88

 SSc vs. other CTD

1.9 (1.0, 3.7)

0.07

4.1 (1.2, 13.3)

0.02

Baseline FVC (per 10% decrease)

1.1 (1.0, 1.2)

0.06

1.2 (1.0, 1.4)

0.10

Baseline DLCO (per 10% decrease)

1.3 (1.1, 1.5)

< 0.001

1.2 (1.0, 1.5)

0.08

Baseline 6MWD (per 100 m decrease)

1.4 (1.1, 1.7)

0.005

1.1 (0.8, 1.4)

0.74

UIP vs. NSIP

2.3 (1.4, 4.0)

0.002

0.9 (0.4, 2.1)

0.80

  1. CTD connective tissue disease, ILD interstitial lung disease, EA East Asian, SA South Asian, FN First Nations, SSc systemic sclerosis, RA rheumatoid arthritis, MCTD mixed connective tissue disease, UIP usual interstitial pneumonia, NSIP non-specific interstitial pneumonia