Patterns of brain structural alteration in COPD with different levels of pulmonary function impairment and its association with cognitive deficits

Table 3 Correlations of imaging parameters with MoCA scores and FEV1 in COPD

Brain regions	MoCA		FEV1
Brain regions	r	P	r	P
GMD
Left superior frontal gyrus	0.233	0.048	0.433	<0.001
Left middle frontal gyrus	0.058	0.616	0.447	<0.001
Left medial orbital gyrus	0.151	0.186	0.600	<0.001
Left pars orbitalis of the inferior frontal gyrus	0.154	0.179	0.544	<0.001
Right orbital part of the inferior frontal gyrus	0.293	0.009	0.659	<0.001
Left supplementary motor cortex	0.105	0.359	0.615	<0.001
Left parahippocampal / fusiform gyrus	0.178	0.119	0.553	<0.001
Right thalamus	0.078	0.495	0.116	0.312
MD
Corpus callosum (body)	−0.232	0.039	− 0.324	0.004
AD
Left superior corona radiata	−0.249	0.027	−0.322	0.004
Right superior corona radiata	−0.300	0.007	−0.271	0.016
RD
Corpus callosum (body)	−0.264	0.019	−0.311	0.005

Abbreviations: MoCA, Montreal Cognitive Assessment; FEV1, forced expiratory volume in 1 s; GMD, grey matter density; COPD, chronic obstructive pulmonary disease; MD, mean diffusivity; AD, axial diffusivity; RD, radial diffusivity

ISSN: 1471-2466