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Table 4 Prognostic factors for survival by univariate and multivariate Cox regression models in all patients

From: Acute exacerbations of fibrosing interstitial lung disease associated with connective tissue diseases: a population-based study

Clinical Variables

Univariate Cox Model

Multivariate Cox Model

HR

95.0% CI

p value

HR

95.0% CI

p value

 WBC count (×109)

1.075

1.041–1.109

<0.001

1.051

1.013–1.090

0.008

 CRP (mg/L)

1.003

1.000–1.006

0.038

1.003

0.999–1.007

0.157

 LDH (U/L)

1.003

1.002–1.004

<0.001

1.000

0.998–1.001

0.430

 ALB (U/L)

0.943

0.987–0.992

0.022

1.000

0.999–1.001

0.545

 D-dimmer

1.048

1.018–1.080

0.002

1.021

0.971–1.074

0.421

 PaO2/FiO2 ratio

0.991

0.998–0.994

<0.001

0.991

0.987–0.994

<0.001

 CT score

1.402

1.195–1.645

<0.001

1.337

1.063–1.682

0.013

 MV

2.877

2.070–4.000

<0.001

–

–

–

 Maximal dosage of methylprednisolone (mg/d)

1.001

1.000–1.001

0.016

1.000

0.999–1.001

0.840

 Immunosuppressant

0.673

0.478–0.947

0.023

–

–

–

 Immunoglobulin

2.103

1.524–2.901

<0.001

–

–

–

 Co-trimoxazole

1.382

1.009–1.892

0.044

–

–

–

 Caspofungin

2.057

1.406–3.009

<0.001

–

–

–

  1. WBC: white blood cell; LDH: lactate dehydrogenase; PaO2/FiO2ratio: Oxygenation index; MV: mechanical ventilation; HRCT: high resolution computed tomography