Acute exacerbations of fibrosing interstitial lung disease associated with connective tissue diseases: a population-based study

Table 5 Prognostic factors for survival by C by univariate and multivariate Cox regression models in the two groups

Clinical Variables	Univariate Cox Model			Multivariate Cox Model
Clinical Variables	HR	95.0% CI	p value	HR	95.0% CI	p value
AE-IPF group
WBC count (×10⁹)	1.071	1.033–1.111	< 0.001	1.069	1.031–1.109	< 0.001
LDH (U/L)	1.002	1.001–1.003	0.003	–	–	–
PaO2/FiO2 ratio	0.993	0.989–0.997	0.001	0.993	0.989–0.997	0.002
CT score	1.703	1.343–2.158	< 0.001	1.573	1.211–2.042	0.001
MV	2.673	1.747–4.087	< 0.001	–	–	–
Maximal dosage of methylprednisolone (mg/d)	1.001	1.000–1.002	0.006	1.000	1.000–1.001	0.534
Immunoglobulin	2.182	1.427–3.338	< 0.001	–	–	–
Caspofungin	1.809	1.038–3.153	0.036	–	–	–
AE-CTD-fILD group
WBC count (×10⁹)	1.098	1.027–1.175	0.006	1.074	1.004–1.150	0.038
LDH (U/L)	1.004	1.002–1.005	< 0.001
PaO2/FiO2 ratio	0.989	0.985–0.994	< 0.001	0.989	0.984–0.994	< 0.001
CT score	1.253	0.993–1.582	0.058	0.975	0.746–1.274	0.852
MV	3.495	2.020–6.047	< 0.001
Maximal dosage of methylprednisolone (mg/d)	1.000	0.999–1.001	0.613	0.999	0.998–1.000	0.277
Immunoglobulin	2.370	1.401–4.009	0.001	–	–	–
Caspofungin	2.741	1.563–4.808	< 0.001	–	–	–

WBC: white blood cell; LDH: lactate dehydrogenase; PaO2/FiO2 ratio: Oxygenation index; MV: mechanical ventilation; HRCT: high resolution computed tomography

ISSN: 1471-2466