Table 2 Results of the pooled and subgroup analyses for the ADRB2 rs1042714 polymorphism and asthma risk
Variable | n | Case/Control | Dominant model comparison | Recessive model comparison | Homozygote genotype comparison | Allelic comparison | Frequence of minor allele (G/(G + C)) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OR[95%CI] | P(Z) | I2 | OR[95%CI] | P(Z) | I2 | OR[95%CI] | P(Z) | I2 | OR[95%CI] | P(Z) | I2 | Case | Control | |||
Total | 52 | 8242/16832 | 0.92 [0.83, 1.02] | 0.097 | 45% | 0.83 [0.70, 0.98] | 0.032 | 44% | 0.84 [0.72, 0.98] | 0.028 | 25% | 0.91 [0.83, 0.99] | 0.029 | 59% | 0.242 | 0.348 |
Adult | 28 | 5022/13609 | 0.89 [0.77, 1.02] | 0.101 | 55% | 0.94 [0.83, 1.07] | 0.372 | 6% | 0.94 [0.81, 1.08] | 0.371 | 0% | 0.92 [0.83, 1.02] | 0.095 | 52% | 0.246 | 0.371 |
Children | 18 | 2498/2510 | 0.97 [0.81, 1.16] | 0.706 | 36% | 0.59 [0.39, 0.88] | 0.009 | 58% | 0.63 [0.43, 0.92] | 0.016 | 46% | 0.86 [0.69, 1.07] | 0.169 | 73% | 0.205 | 0.234 |
East-Asian | 27 | 4555/4217 | 0.94 [0.85, 1.04] | 0.249 | 20% | 0.81 [0.65, 1.01] | 0.057 | 0% | 0.82 [0.66, 1.03] | 0.090 | 0% | 0.93 [0.85, 1.01] | 0.085 | 25% | 0.164 | 0.161 |
Indian | 3 | 672/687 | 0.85 [0.68, 1.07] | 0.160 | 18% | 1.04 [0.70, 1.54] | 0.862 | 0% | 0.95 [0.63, 1.43] | 0.806 | 0% | 0.91 [0.76, 1.09] | 0.294 | 0% | 0.234 | 0.250 |
Arab | 2 | 137/196 | 0.98 [0.63, 1.51] | 0.249 | 0% | 1.14 [0.49, 2.61] | 0.764 | 0% | 1.11 [0.47, 2.60] | 0.810 | 0% | 1.01 [0.71, 1.43] | 0.972 | 0% | 0.270 | 0.273 |
Hispanic-Latinos | 4 | 605/982 | 0.67 [0.41, 1.10] | 0.108 | 75% | 0.54 [0.13, 2.25] | 0.394 | 90% | 0.54 [0.18, 1.64] | 0.276 | 82% | 0.61 [0.33, 1.15] | 0.129 | 91% | 0.202 | 0.277 |
non-Hispanic Blacks | 2 | 194/162 | 1.06 [0.53, 2.09] | 0.875 | 58% | 0.88 [0.40, 1.94] | 0.758 | 0% | 0.94 [0.41, 2.12] | 0.876 | 0% | 1.03 [0.74, 1.45] | 0.845 | 41% | 0.309 | 0.290 |
Caucasian | 14 | 2079/10588 | 0.98 [0.81, 1.19] | 0.840 | 51% | 0.90 [0.78, 1.03] | 0.126 | 29% | 0.92 [0.79, 1.08] | 0.319 | 11% | 0.94 [0.82, 1.07] | 0.338 | 50% | 0.418 | 0.437 |
HWE(P > 0.05) | 35 | 5552/14306 | 0.89 [0.80, 0.99] | 0.034 | 32% | 0.94 [0.83, 1.06] | 0.299 | 0% | 0.94 [0.81, 1.08] | 0.358 | 0% | 0.91 [0.84, 0.99] | 0.021 | 28% | 0.258 | 0.366 |
HWE(P < 0.05) | 16 | 2478/2474 | 0.95 [0.77, 1.17] | 0.637 | 59% | 0.70 [0.47, 1.06] | 0.089 | 69% | 0.73 [0.51, 1.05] | 0.088 | 58% | 0.87 [0.70, 1.09] | 0.239 | 79% | 0.221 | 0.248 |