Table 2 Distribution of KRAS and BRAF mutations according to patients’ characteristics
Characteristics | Number of patients (%) | KRAS mutated cases | BRAF mutated cases | ||||
|---|---|---|---|---|---|---|---|
No. | % | p | No. | % | p | ||
Total cases analyzed | 1047 | 231 | 22.1 | Â | 34 | 3.2 | Â |
Sex | |||||||
 Males | 693 (66) | 169 | 24.4 | 0.018 | 25 | 3.6 | 0.462 |
 Females | 354 (34) | 61 | 17.2 | 9 | 2.5 | ||
Age at diagnosis | |||||||
 ≤ 50 years | 94 (9) | 24 | 25.5 | 0.472* | 3 | 3.2 | 1.000* |
 51–60 years | 189 (18) | 46 | 24.3 | 7 | 3.7 | ||
 61–70 years | 394 (38) | 78 | 19.9 | 10 | 2.5 | ||
 > 70 years | 370 (35) | 83 | 22.4 | 14 | 3.6 | ||
Smoking habitus | |||||||
 Smoker | 336 (32) | 74 | 22.0 | 0.001** | 14 | 4.2 | 0.411** |
 Former smoker | 367 (35) | 89 | 24.3 | 10 | 2.7 | ||
 Never smoker | 139 (13) | 14 | 10.1 | 2 | 1.4 | ||
 Unknown | 205 (20) | 54 | 26.3 |  | 8 | 3.9 |  |
Type of sample | |||||||
 Primary tumor | 889 (85) | 197 | 22.2 | 0.940 | 29 | 3.3 | 1.000 |
 Metastasis | 158 (15) | 34 | 21.5 | 5 | 3.2 | ||
Sample’s origin | |||||||
 Biopsy | 848 (81) | 193 | 22.8 | 0.304 | 28 | 3.3 | 0.987 |
 Surgery | 199 (19) | 38 | 19.1 | 6 | 3.0 | ||