The economic burden of systemic sclerosis related pulmonary arterial hypertension in Australia

BMC Pulmonary Medicine

Table 6 Determinants of above median annual total healthcare cost and its components in SSc-PAH in multivariable logistic regression

Determinants of annual total healthcare cost	OR (95%CI)	p-value
Female	2.42 (0.8-7.6)	0.13
Age at onset of PAH, years	1.00 (0.9-1.0)	0.76
Caucasian ethnicity	2.89 (0.4-19.3)	0.27
Diffuse disease subtype	1.74 (0.7-4.5)	0.26
Digital ulceration	1.82 (0.8-3.9)	0.13
Mild ILD^ (FVC>70%)	1.63 (0.8-3.6)	0.23
Combination PAH specific therapy	1.01 (0.5-2.2)	0.97
Severe PAH*	2.46 (1.1-5.6)	0.03
Determinants of hospital cost	OR (95%CI)	p-value
Female	3.08 (0.9-9.7)	0.05
Caucasian ethnicity	1.94 (0.4-10.2)	0.43
Diffuse disease subtype	1.38 (0.6-3.4)	0.49
Severe PAH*	2.25 (1.1-5.0)	0.04
Mild ILD^ (FVC>70%)	1.97 (0.9-4.3)	0.09
Combination PAH specific therapy	1.35 (0.6-2.8)	0.43
Determinants of ED cost	OR (95%CI)	p-value
Female	1.38 (0.4-5.1)	0.62
Age at onset of PAH, years	1.00 (0.9-1.1)	0.72
Caucasian ethnicity	1.52 (0.2-10.6)	0.67
Diffuse disease subtype	1.26 (0.5-3.3)	0.64
Severe PAH*	1.61 (0.6-4.0)	0.31
COAD	5.44 (1.2-25.6)	0.03
Combination PAH specific therapy	0.65 (0.3-1.5)	0.31
Determinants of MBS cost	OR (95%CI)	p-value
Female	1.67 (0.6-4.8)	0.34
Age at onset of PAH, years	1.01 (0.9-1.1)	0.47
Caucasian ethnicity	6.89 (0.8-60.3)	0.08
Diffuse disease subtype	1.49 (0.6-3.5)	0.35
Severe PAH*	1.02 (0.5-2.1)	0.96
Combination PAH specific therapy	1.57 (0.8-3.2)	0.22

Abbreviations: pulmonary arterial hypertension (PAH), interstitial lung disease (ILD), chronic obstructive airway disease (COAD), forced vital capacity (FVC), emergency department (ED) Medical Benefit Schedule (MBS),
^ to ensure that we were only evaluating WHO Group 1 PAH in our SSc cohort, patients were excluded if they had Group 1 PAH and co-existing ILD with a FVC <70% and an abnormal high-resolution computer tomography (HRCT) of the chest. V/Q scanning was preformed to exclude pulmonary hypertension due to chronic thromboembolism
*severe PAH defined by the presence of WHO Functional Class IV, presence of a pericardial effusion, 6MWD <300m, right atrial pressure on right heart catheter of >15 and cardiac index of <2.

ISSN: 1471-2466