Table 1 Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) figure for the REAL study

Visit

V0

TC1

TC2

TC3

UC

V1

Informed consent

X

Inclusion/exclusion criteria

X

Demography (date of birth, ethnicity, gender, education, marital status, socioeconomic status, insurance status, residence area, occupation)

X

Physical examination

X

X

Smoking history

X

COPD history

X

Disease severity GOLD 2016

X

X

Comorbidities, other respiratory diseases

X

X

X

X

X

X

Exacerbations

X

X

X

X

X

X

Symptoms

X

X

X

X

X

X

Spirometry and bronchial dilation if available

X

X

X

CAT, mMRC

X

X

X

X

X

COPD-Q

X

X

FENO if available

X

X

X

Chest CT imaging if available

X

X

X

Induced sputum test if available

X

X

X

Lab tests (blood gases, C-reactive protein and hematology) if available

X

X

X

COPD medications

X

X

X

X

X

X

COPD non-pharmacological treatment

X

X

X

X

X

X

Total COPD treatment expenses

X

X

X

X

X

X