Table 2 Hemodynamic, pulmonary function and CPET parameters
From: Prognostic value of cardiopulmonary exercise testing in patients with systemic sclerosis
Parameter | N | Group 1 dcSSc, n = 88 | Group 2 lcSSc, n = 122 | p-value (group 1 vs. 2) |
|---|---|---|---|---|
Echocardiography available (n) | 192 | 80 (90.9%) | 112 (91.8%) | 0.819 |
TR detected (n) | 169 | 65 (80.3%) | 104 (89.7%) | 0.063 |
Estimated RVsys (mmHg) | 159 | 31 (25; 38) | 32 (25; 45) | 0.498 |
Right heart catheter available (n) | 139 | 49 (55.7%) | 90 (73.8%) | 0.006 |
RAPmean (mmHg) | 135 | 5 (2; 7) | 5 (3; 7) | 0.653 |
PAPmean (mmHg) | 136 | 23 (16; 33) | 21 (15; 30) | 0.161 |
PAPmean ≥ 25 mmHg | 136 | 20 (42.6%) | 32 (36.0%) | 0.451 |
PAWP (mmHg) | 136 | 9 (5; 13) | 7 (6; 10) | 0.059 |
PVR (Wood units) | 134 | 2.68 (1.62; 5.34) | 2.17 (1.49; 4.94) | 0.587 |
Cardiac output (L∙min−1) | 123 | 5.17 (4.40; 5.93) | 4.94 (4.22; 5.88) | 0.251 |
PAH (n) | 134 | 13 (27.7%) | 25 (28.7%) | 0.895 |
TLC (% predicted) | 205 | 93.8 (79.0; 107.0) | 103.6 (90.9; 115.9) | 0.026 |
VC (% predicted) | 206 | 85.2 (75.8; 102.0) | 100.5 (83.3; 109.0) | 0.005 |
FVC (% predicted) | 201 | 87 (75; 105) | 97 (84; 110) | 0.037 |
Proportion of patients with FVC ≤70% predicted | 201 | 17 (20.0%) | 10 (8.6%) | 0.019 |
FEV1 (% predicted) | 206 | 90 (77; 104) | 95 (84; 107) | 0.002 |
FEV1/FVC (%) | 204 | 83 (78; 90) | 79 (74; 86) | 0.571 |
RV (% predicted) | 204 | 104 (84; 124) | 114 (95; 138) | 0.468 |
RV/TLC (% predicted) | 194 | 105,1 (92,6;122,2) | 99,1 (87,1;111,7) | 0.110 |
DLCO (% predicted) | 190 | 60 (43; 77) | 68 (45; 84) | 0.616 |
Proportion of patients with DLCO ≤60% predicted | 190 | 40 (50.6%) | 42 (37.8%) | 0.079 |
KCO (% predicted) | 191 | 74.0 (56.6; 89.2) | 71.8 (59.8; 86.3) | 0.616 |
FVC (% pred.)/‌DLCO (% pred.) | 185 | 1.48 (1.22; 1.94) | 1.42 (1.22; 1.96) | 0.719 |
6-MWD (m) | 96 | 447 (372; 525) | 423 (370; 478) | 0.798 |
Maximum power (Watts) | 209 | 84 (68; 100) | 84 (68; 116) | 0.723 |
Maximum power (% predicted) | 209 | 87 (62; 117) | 97 (75; 118) | 0.180 |
VO2@AT in % of peakVO2 predicted | 197 | 41.5 (31.8; 55.8) | 41.0 (35.3; 47.1) | 0.726 |
peakVO2 (mL∙min−1) | 210 | 1171 (947; 1416) | 1180 (899; 1476) | 0.780 |
peakVO2 (% of predicted) | 210 | 72.2 (58.4; 84.6) | 75.2 (58.3; 90.0) | 0.263 |
peakVO2/peakHR (L) | 207 | 9.1 (7.2; 11.0) | 9.0 (6.9; 10.8) | 0.953 |
VE/VCO2-slope | 200 | 31.6 (27.0; 40.0) | 33.6 (28.0; 42.0) | 0.117 |
VE/VCO2@rest | 208 | 37 (32; 45) | 38 (32; 43) | 0.726 |
VE/VCO2@ AT | 206 | 32 (29; 40) | 34 (29; 42) | 0.121 |
petCO2@rest | 205 | 30.8 (27.5; 34.0) | 30.8 (26.5; 34.0) | 0.953 |
petCO2@AT | 203 | 33.8 (29.8; 38.0) | 33.0 (28.0; 37.9) | 0.291 |
VE/MVV (%) | 210 | 54.1 (43.5; 68.1) | 55.2 (44.8; 63.4) | 0.780 |
Proportion of VE/MVV > 80% (n) | 210 | 9 (10.2%) | 11 (9.0%) | 0.768 |