Table 1 Chemotherapeutic regimens administered with bortezomib for treatment of multiple myeloma and pre-existing scleromyxedema with pulmonary symptoms
From: Severe but reversible pulmonary hypertension in scleromyxedema and multiple myeloma: a case report
Cycle # | Agent 1 | Dose | Agent 2 | Dose | Agent 3 | Dose | Agent 4 | Dose |
|---|---|---|---|---|---|---|---|---|
1 | Bortezomib D1, D8, D15 | 2.5 IV | Dexamethasone Weekly | 20 mg PO | IVIG Weekly | 40 g IV | – | – |
2 | Bortezomib D1, D8, D15 | 2.6 S/Q | Dexamethasone Weekly | 20 mg PO | IVIG Weekly | 40 g IV | – | – |
3 | Bortezomib D1, D8, D15 | 2.6 S/Q | Dexamethasone Weekly | 20 mg PO | IVIG Weekly | 40 g IV | – | – |
4 | Bortezomib D1, D8, D15 | 2.6 S/Q | Dexamethasone Weekly | 20 mg PO | IVIG Weekly | 40 g IV | – | – |
5 | Bortezomib D1, D8, D15 | 2.6 S/Q | Dexamethasone Weekly | 20 mg PO | IVIG Weekly | 40 g IV | – | – |
6 | Bortezomib D1, D8, D15 | 2.6 S/Q | Dexamethasone Weekly | 20 mg PO | IVIG Weekly | 40 g IV | – | – |
7 | Bortezomib D1 only, developed neuropathy | 2.6 S/Q | Dexamethasone Weekly | 20 mg PO | IVIG Weekly | 40 g IV |  |  |
1 | Bortezomib D1, D8, D15 | 1.5 mg IV | Dexamethasone Weekly | 20 mg PO | Cyclophosphamide D1, D8, D15 | 300 mg IV | IVIG Weekly | 40 g IV |
2 | Bortezomib D1, D8, D15 | 1.5 mg IV | Dexamethasone Weekly | 20 mg PO | Cyclophosphamide D1, D8, D15 | 300 mg IV | IVIG Weekly | 40 g IV |
3 | Bortezomib D1, D8, D15 | 1.6 mg IV | Dexamethasone Weekly | 20 mg PO | Cyclophosphamide D1, D8, D15 | 600 mg IV | IVIG Weekly | 40 g IV |
4 | Bortezomib D1, D8, D15 | 1.6 mg IV | Dexamethasone Weekly | 20 mg PO | Cyclophosphamide D1, D8, D15 | 600 mg IV | IVIG Weekly | 40 g IV |
Chemotherapy break– | – | Dexamethasone Weekly | 20 mg PO | – | – | IVIG Weekly | 40 g IV | |
5 | Bortezomib D1, D8, D15 | 1.2 mg IV | Dexamethasone Weekly | 20 mg PO | Cyclophosphamide D1, D8, D15 | 600 mg IV | IVIG Weekly | 40 g IV |
6 | Bortezomib D1, D8, D15 | 1.5 mg IV | Dexamethasone Weekly | 20 mg PO | Cyclophosphamide D1, D8, D15 | 480 mg IV | IVIG Weekly | 40 g IV |
7 | Bortezomib D1, D8, D15 | 2 mg IV | Dexamethasone Weekly | 20 mg PO | Cyclophosphamide D1, D8, D15 | 600 mg IV | IVIG Weekly | 40 g IV |
8 | Bortezomib D1, D8, D15 | 1.6 mg IV | Dexamethasone Weekly | 20 mg PO | Cyclophosphamide D1, D8, D15 | 600 mg IV | IVIG Weekly | 40 g IV |
9 | Bortezomib D1, D8, D15 | 2 mg IV | Dexamethasone Weekly | 20 mg PO | Cyclophosphamide D1, D8, D15 | 500 mg IV | IVIG Weekly | 40 g IV |
|  | Iron infusion | 510 mg IV | – | – | – | – | – | – |
| Â | Passed away | N/A | N/A | N/A | N/A | N/A | N/A | N/A |