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Table 2 Spearman correlation coefficients (rS) between total cell number, percentage of neutrophils, total protein and inflammatory markers in induced sputum (values 24 h after all ZnO exposures were considered) with 95% confidence intervals and p-values

From: Airway inflammation after inhalation of nano-sized zinc oxide particles in human volunteers

 Total cell numberNeutrophils [%]Total Protein [μg/mL]IL-8 [pg/mL]MMP-9 [ng/mL]TIMP-1 [ng/mL]8-iso-PGF [pg/mL]Substance P [pg/mL]IL-6 [pg/mL]
Total cell number
[×  105]
10.51*
0.35–0.67
< 0.0001
0.52*
0.37–0.67
< 0.0001
0.44*
0.28–0.61
< 0.0001
0.60*
0.46–0.73
< 0.0001
0.58*
0.45–0.71
< 0.0001
−0.07
-0.26-0.13
0.4931
−0.21*
-0.40- -0.02
0.0315
0.35*
0.18–0.52
0.0002
Neutrophils
[%]
 10.70*
0.60–0.78
< 0.0001
0.69*
0.58–0.82
< 0.0001
0.81*
0.73–0.89
< 0.0001
0.79*
0.70–0.87
< 0.0001
0.17
-0.02-0.36
0.3120
−0.26*
-0.46- -0.07
0.0008
0.61*
0.48–0.75
< 0.0001
Total protein
[μg/mL]
  10.85*
0.78–0.92
< 0.0001
0.84*
0.73–0.89
< 0.0001
0.88*
0.82–0.96
< 0.0001
0.34*
0.19–0.50
0.0003
−0.23*
-0.42- -0.04
0.0193
0.56*
0.43–0.70
< 0.0001
IL-8
[pg/mL]
   10.87*
0.82–0.95
< 0.0001
0.90*
0.85–0.96
< 0.0001
0.37*
0.22–0.52
0.0001
−0.29*
-0.48- - 0.10
0.0046
0.59*
0.47–0.71
< 0.0001
MMP-9
[ng/mL]
    10.95*
0.94–0.97
< 0.0001
0.24*
0.08–0.40
0.0146
−0.28*
− 0.46- -0.09
0.0046
0.68*
0.58–0.77
< 0.0001
TIMP-1
[ng/mL]
     10.19*
0.02–0.35
0.0497
−0.33*
-0.41- -0.15
0.0008
0.65*
0.54–0.77
< 0.0001
8-iso-PGF
[pg/mL]
      10.17
-0.03-0.38
0.0791
0.05
-0.14-0.23
0.6389
Substance P
[pg/mL]
       1−0.24*
-0.44- -0.03
0.0146
IL-6
[pg/mL]
        1
  1. Correlations with p < 0.05 are marked with asterisks