Fig. 2

Case 2 – Solitary pulmonary nodule in apical segment of left upper lobe. a: 2.7 cm solitary pulmonary nodule in apical segment of left upper lobe. b: An eccentric rEBUS orientated lesion localized at LB1 + 2ai with no surrounding vessels. c: Placement of 1.1 mm flexible cryoprobe through GS into the target lesion at apical segment of left upper lobe under fluoroscopic guidance. d: Gross appearance of cryobiopsy specimen (left to right): 2 mm with 3 s activation (specimen retrieved through GS), 3 mm with 4 s activation and 3 mm with 5 s activation. e: Structural integrity of lung tissue was maintained with cryobiopsy which revealed fibrotic alveolar tissue infiltrated by tumour. (Hematoxylin & Eosin, × 100 magnification). f: High power examination revealed tumour infiltration arranged in glandular pattern with large and round pleomorpic hyperchromatic nuclei and prominent nuceloli. Immunohistochemistry was positive for CK7 and TTF-1, consistent with adenocarcinoma of lung. (Hematoxylin & Eosin, × 400 magnification)