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Table 2 Step 1: IVW fixed-effect MR estimates of the causal effect of BMI on CpG methylation

From: Role of DNA methylation in the association of lung function with body mass index: a two-step epigenetic Mendelian randomisation study

 

ECRHS + NFBC (n = 1151)

SAPALDIA (n = 906)

CpG

Gene

Chromosomal position

MR estimate (SE)a

P

I2b

MR estimate (SE)a

P

I2b

cg09046979

SBK1

16:28333134

−0.021 (0.010)

0.03

41%

0.007 (0.015)

0.6

39%

cg12580248

NPIPB11

16:29412940

0.022 (0.012)

0.08

43%

  1. aChange in methylation (unit is %) per one-unit increase in BMI (kg/m2); MR Mendelian randomisation; SE Standard error. bBetween-instrument heterogeneity