Skip to main content

Table 2 Step 1: IVW fixed-effect MR estimates of the causal effect of BMI on CpG methylation

From: Role of DNA methylation in the association of lung function with body mass index: a two-step epigenetic Mendelian randomisation study

 ECRHS + NFBC (n = 1151)SAPALDIA (n = 906)
CpGGeneChromosomal positionMR estimate (SE)aPI2bMR estimate (SE)aPI2b
cg09046979SBK116:28333134−0.021 (0.010)0.0341%0.007 (0.015)0.639%
cg12580248NPIPB1116:294129400.022 (0.012)0.0843%
  1. aChange in methylation (unit is %) per one-unit increase in BMI (kg/m2); MR Mendelian randomisation; SE Standard error. bBetween-instrument heterogeneity