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Table 2 Concentrations of ADA, IFN-γ, and IL-27 in pleural fluid according to study cohort and age*

From: Influence of age on the diagnostic accuracy of soluble biomarkers for tuberculous pleural effusion: a post hoc analysis

  

Beijing cohort (n = 154)

Wuhan cohort (n = 120)

Total (n = 274)

 

Variable

TPE

MPE

PPE

Miscellaneous

TPE

MPE

PPE

Miscellaneous

TPE

MPE

PPE

Miscellaneous

≤40

ADA, U/L

55.6 ± 5.3†

8.47 ± 2.4

2.6

8.5 ± 2.4

62.0 ± 12.3†

9.0 ± 1.4

14.1 ± 2.4

21.0

58.0 ± 5.5†

8.7 ± 1.3

10.2 ± 4.1

9.8 ± 3.2

IFN-γ, ng/L

3407.1 ± 736.2‡

44.7 ± 8.7

42.9

44.7 ± 8.7

2297.5 ± 543.0‡

16.4 ± 1.4

14.8 ± 0.8

104.7

2998.2 ± 508.6‡

30.5 ± 7.4

24.2 ± 9.4

49.6 ± 9.7

IL-27, ng/L

875.8 ± 51.3†

279.0 ± 24.9

198.2

279.0 ± 24.9

853.8 ± 49.8†

240.4 ± 37.7

452.7 ± 138.4

240.4

867.7 ± 36.9†

259.7 ± 22.0

367.9 ± 116.5

381.9 ± 106.7

>40

ADA, U/L

43.5 ± 4.9†

16.0 ± 1.4

14.9 ± 1.6

16.1 ± 2.2

41.8 ± 4.0†

13.6 ± 1.3

14.7 ± 1.3

18.3 ± 2.2

42.7 ± 4.4†

14.8 ± 1.3

14.8 ± 1.4

17.2 ± 2.2

IFN-γ, ng/L

2176.4 ± 641.9‡

35.7 ± 3.3

59.8 ± 17.4

102.0 ± 54.6

2508.5 ± 660.5‡

41.3 ± 7.3

67.3 ± 10.5

111.9 ± 63.5

2342.2 ± 651.2‡

38.5 ± 5.2

63.6 ± 14.0

107.0 ± 59.1

IL-27, ng/L

907.7 ± 49.1†

299.3 ± 13.8

273.1 ± 16.5

251.7 ± 14.1

900.0 ± 52.9†

292.0 ± 13.5

289.6 ± 18.1

253.6 ± 20.5

903.9 ± 51.0†

295.7 ± 13.6

281.3 ± 17.3

252.7 ± 17.3

  1. *Data are presented as mean ± SEM or median (25th - 75th centile). †p < 0.001 compared with each non-TPE group using analysis of variance (ANOVA) followed by Bonferroni’s test; ‡p < 0.001 compared with the corresponding serum using paired t test. ADA, adenosine deaminase; IFN, interferon; IL, interleukin; MPE, malignant pleural effusion; PPE, parapneumonic pleural effusion; TPE, tuberculous pleural effusion
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BMC Pulmonary Medicine

ISSN: 1471-2466

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