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Table 2 Concentrations of ADA, IFN-γ, and IL-27 in pleural fluid according to study cohort and age*

From: Influence of age on the diagnostic accuracy of soluble biomarkers for tuberculous pleural effusion: a post hoc analysis

  Beijing cohort (n = 154)Wuhan cohort (n = 120)Total (n = 274)
 VariableTPEMPEPPEMiscellaneousTPEMPEPPEMiscellaneousTPEMPEPPEMiscellaneous
≤40ADA, U/L55.6 ± 5.3†8.47 ± 2.42.68.5 ± 2.462.0 ± 12.3†9.0 ± 1.414.1 ± 2.421.058.0 ± 5.5†8.7 ± 1.310.2 ± 4.19.8 ± 3.2
IFN-γ, ng/L3407.1 ± 736.2‡44.7 ± 8.742.944.7 ± 8.72297.5 ± 543.0‡16.4 ± 1.414.8 ± 0.8104.72998.2 ± 508.6‡30.5 ± 7.424.2 ± 9.449.6 ± 9.7
IL-27, ng/L875.8 ± 51.3†279.0 ± 24.9198.2279.0 ± 24.9853.8 ± 49.8†240.4 ± 37.7452.7 ± 138.4240.4867.7 ± 36.9†259.7 ± 22.0367.9 ± 116.5381.9 ± 106.7
>40ADA, U/L43.5 ± 4.9†16.0 ± 1.414.9 ± 1.616.1 ± 2.241.8 ± 4.0†13.6 ± 1.314.7 ± 1.318.3 ± 2.242.7 ± 4.4†14.8 ± 1.314.8 ± 1.417.2 ± 2.2
IFN-γ, ng/L2176.4 ± 641.9‡35.7 ± 3.359.8 ± 17.4102.0 ± 54.62508.5 ± 660.5‡41.3 ± 7.367.3 ± 10.5111.9 ± 63.52342.2 ± 651.2‡38.5 ± 5.263.6 ± 14.0107.0 ± 59.1
IL-27, ng/L907.7 ± 49.1†299.3 ± 13.8273.1 ± 16.5251.7 ± 14.1900.0 ± 52.9†292.0 ± 13.5289.6 ± 18.1253.6 ± 20.5903.9 ± 51.0†295.7 ± 13.6281.3 ± 17.3252.7 ± 17.3
  1. *Data are presented as mean ± SEM or median (25th - 75th centile). †p < 0.001 compared with each non-TPE group using analysis of variance (ANOVA) followed by Bonferroni’s test; ‡p < 0.001 compared with the corresponding serum using paired t test. ADA, adenosine deaminase; IFN, interferon; IL, interleukin; MPE, malignant pleural effusion; PPE, parapneumonic pleural effusion; TPE, tuberculous pleural effusion