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Table 3 Top metabolites associated with FEV1/FVC - Results of the discovery and replication studies

From: A cross-omics integrative study of metabolic signatures of chronic obstructive pulmonary disease

Metabolite Discovery meta-analysis Replication meta-analysis
β SE P-value Directiona N β SE P-value Directionb N
Valine 0.005 0.001 2.5 × 10–4 +++ 3324 − 0.0015 0.0023 0.5314 −+ 1460
GlycA −0.005 0.001 4.5 × 10–4 ––– 3324 − 0.0010 0.0022 0.6438 –– 1463
Albumin 0.004 0.001 0.0047 +++ 3324 0.0045 0.0021 0.0353 ++ 1463
Glutamine −0.003 0.001 0.0097 ––– 3323 0.0029 0.0023 0.1923 ++ 1393
Triglycerides in very large HDL −0.003 0.001 0.0160 ––– 3324 0.0031 0.0022 0.1491 ++ 1469
Phenylalanine −0.003 0.001 0.0334 ––– 3324 − 0.0012 0.0023 0.5899 +− 1450
  1. Model adjusted for age, sex, BMI, LLM use and smoking status; HDL high density lipoprotein, β effect size, SE standard error; Direction - direction of the effect in individual studies; N - meta-analysis sample size; a Direction of the effect in the discovery studies in order: RS-III-2, RS-E5, RS-I-4; b Direction of the effect in the replication studies in order: LLDEEP, PIVUS; In bold: significant results (P < 0.001)