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Table 2 Unadjusted treatment patterns

From: Treatment patterns, healthcare resource utilization, and costs among patients with idiopathic pulmonary fibrosis treated with antifibrotic medications in US-based commercial and Medicare Supplemental claims databases: a retrospective cohort study

  All Patients Pirfenidone Nintedanib P Value1
N = 1455 N = 799 N = 656
Follow-Up
 Days of follow-up after index date, mean (SD) 465.0 (343.9) 480.2 (351.4) 446.6 (334.0) 0.064
Adherence
 Total days with index drug, mean (SD)2 269.0 (277.8) 282.7 (289.7) 252.4 (261.8) 0.038
 PDC during follow-up, mean (SD) 0.66 (0.35) 0.66 (0.35) 0.66 (0.35) 0.910
 PDC ≥ 0.80, n (%) 721 (49.6) 390 (48.8) 331 (50.5) 0.532
Persistence
 Duration of persistence in days, mean (SD)3 286.8 (301.4) 305.2 (314.7) 264.4 (282.9) 0.010
 Discontinuation or switching, n (%)3 610 (41.9) 326 (40.8) 284 (43.3) 0.338
  Days on index medication in patients who discontinued or switched, mean (SD) 167.4 (189.8) 171.2 (190.5) 163.1 (189.4) 0.598
 Switching, n (%) 144 (9.9) 86 (10.8) 58 (8.8) 0.222
  Days on index medication in patients who switched, mean (SD) 297.9 (210.1) 251.4 (184.7) 366.9 (227.5) 0.001
Other discontinuation-related outcomes
 Lung transplant, n (%) 82 (5.6) 53 (6.6) 29 (4.4) 0.069
  Discontinuation before lung transplant, n (%)3,4 36 (43.9) 21 (39.6) 15 (51.7) 0.291
 Re-initiation of index medication, n (%)5 101 (16.1) 61 (17.8) 40 (14.0) 0.197
  Days to re-initiation, mean (SD)6 157.3 (122.0) 150.4 (107.4) 167.9 (142.2) 0.484
  1. PDC proportion of days covered, SD standard deviation
  2. 1 Pirfenidone vs. nintedanib
  3. 2 To account for titration, an additional 7 days were added to the day supply of the first pirfenidone prescription claim, unless the supply was 207 pills for 30 days, which is correct if following the recommended titration schedule
  4. 3 Patients with a lung transplant before the end of a gap of ≥60 days were not considered to have discontinued
  5. 4 Among those with a lung transplant
  6. 5 Among those who discontinued treatment
  7. 6The minimum time to re-initiation is 61 days (as discontinued is defined as a gap if 60 days or more)