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Table 3 Univariate and multivariate Cox analysis of variables considered for OS of SCLC patients

From: Prognostic significance of serum osteopontin levels in small cell lung cancer

Characteristics Univariate Multivariate
HR 95% CI P HR 95% CI P
Gender
(Male vs. Female)
3.563 0.496–25.582 0.206 2.264 0.382–13.404 0.368
Age (< 60 vs. ≥60) 0.819 0.140–4.806 0.825 2.091 0.514–8.502 0.302
Disease stage
(Limited vs. Extended)
4.277 1.233–14.835 0.022 3.429 1.096–10.726 0.034
Lymph node metastasis (N0 vs. N1–3) 0.585 0.157–2.182 0.424 2.358 0.606–9.181 0.216
PS (0–1 vs. 2–3) 4.820 1.196–19.424 0.027 4.004 1.281–12.513 0.017
Smoking history
(Ever vs. Never)
1.719 0.551–5.365 0.351 0.649 0.218–1.933 0.438
Pre-OPN
(Negative vs. Positive)
2.662 0.908–7.807 0.075 0.305 0.091–1.106 0.053
After-OPN
(Negative vs. Positive)
4.936 1.793–13.586 0.002 6.114 1.661–22.510 0.006
  1. CI, confidence interval; HR, hazard ratio; PS, performance status; OPN, osteopontin; OS, overall survival