Prognostic significance of serum osteopontin levels in small cell lung cancer

BMC Pulmonary Medicine

Table 3 Univariate and multivariate Cox analysis of variables considered for OS of SCLC patients

Characteristics	Univariate			Multivariate
Characteristics	HR	95% CI	P	HR	95% CI	P
Gender (Male vs. Female)	3.563	0.496–25.582	0.206	2.264	0.382–13.404	0.368
Age (< 60 vs. ≥60)	0.819	0.140–4.806	0.825	2.091	0.514–8.502	0.302
Disease stage (Limited vs. Extended)	4.277	1.233–14.835	0.022	3.429	1.096–10.726	0.034
Lymph node metastasis (N₀ vs. N_1–3)	0.585	0.157–2.182	0.424	2.358	0.606–9.181	0.216
PS (0–1 vs. 2–3)	4.820	1.196–19.424	0.027	4.004	1.281–12.513	0.017
Smoking history (Ever vs. Never)	1.719	0.551–5.365	0.351	0.649	0.218–1.933	0.438
Pre-OPN (Negative vs. Positive)	2.662	0.908–7.807	0.075	0.305	0.091–1.106	0.053
After-OPN (Negative vs. Positive)	4.936	1.793–13.586	0.002	6.114	1.661–22.510	0.006

CI, confidence interval; HR, hazard ratio; PS, performance status; OPN, osteopontin; OS, overall survival

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