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Table 2 Change from baseline to last follow-up in asthma patients with or without previous mepolizumab treatment

From: Efficacy of benralizumab for patients with severe eosinophilic asthma: a retrospective, real-life study

  all patients(n = 24) previous mepolizumab treatment (−) (n = 13) previous mepolizumab treatment (+) (n = 11) P value between two groups at baseline
baseline last follow up P value baseline last follow up P value baseline last follow up P value P value
peripheral blood eosinophil counts (/μl) 292 (312) 0 (0) < 0.0001 458 (338) 0 (0) 0.0015 95 (88) 0 (0) 0.0033 0.0005
peripheral blood basophil counts (/μl) 35 (27) 7 (9) < 0.0001 35 (26) 6 (5) 0.0015 35 (30) 8 (13) 0.0033 0.95
serum IgE (IU/ml) 232(198) 325 (674) 0.70 263 (186) 232 (225) 0.48 196 (213) 436 (980) 0.88 0.27
FeNO (ppb) 59 (39) 67 (53) 0.41 64 (43) 71 (58) 0.70 52 (32) 61 (47) 0.40 0.53
%FVC (%) 94.9 (14.9) 97.9 (14.3) 0.11 96.1 (16.6) 101.5 (14.2) 0.028 93.4 (13.2) 93.7 (13.9) 0.76 0.52
%FEV1 (%) 78.4 (21.9) 81.9 (21.2) 0.017 79.8 (26.2) 84.6 (24.1) 0.006 76.8 (16.6) 78.8 (17.8) 0.53 0.98
FEV1/FVC (%) 67.2 (10.8) 68.4 (12.3) 0.29 67.1 (12.1) 67.9 (12.5) 0.35 67.2 (9.7) 69.0 (12.7) 0.53 0.75
FEV1 (ml) 1978 (596) 2057 (606) 0.07 1936 (783) 2053 (778) 0.017 2026 (275) 2061 (346) 0.96 0.04
%PEF (%) 83.9 (24.8) 84.1 (24.4) 0.72 86.6 (29.9) 88.0 (27.5) 0.70 80.6 (17.9) 79.0 (19.8) 0.22 0.88
ACT (pts) 19.2 (4.8) 20.3 (4.9) 0.08 17.8 (5.9) 20.2 (5.5) 0.08 20.9 (1.8) 20.3 (4.3) 0.51 0.51
number of annual exacerbations 2.8 (3.4) 1.8 (3.2) 0.28 3.6 (4.0) 1.7 (3.5) 0.10 1.8 (2.3) 2.0 (2.8) 0.67 0.31
prednisolone equivalent dose (mg/day) 5.6 (4.2) 3.3 (2.5) 0.11 6.1 (4.7) 3.0 (2.6) 0.11 4.3 (2.5) 4.3 (2.5) 0.74
  1. Data are presented as the mean (standard deviation) and were analyzed using the Wilcoxon signed rank test
  2. P values with sufficient power that were re-evaluated by a post-hoc power analysis
  3. Abbreviations: FeNO fractional exhaled nitric oxide, FVC forced vital capacity, FEV1 forced expiratory volume in one second, PEF peak expiratory flow, ACT Asthma Control Test, ppb parts-per-billion