Table 3 Purported triggers of SR
Mechanism | Potential Explanations |
|---|---|
Biopsy | • Damage to supplying vasculature [29] • Immune response triggered by local inflammation [29] |
Immunological | • NK activation [56] • Infection-related immune upregulation [57] • CD8+ cell infiltration [58] |
Hormonal | • Down-regulation of tumour proliferation pathways [59] |
Intrinsic regression | • Upregulation of apoptotic pathways [60] • Return of tumour cell differentiation [61] • Removal of carcinogen [62] |