Table 1 Clinical characteristics of IgG4-RD patients
From: Lung nodules and IgG4 related disease: a single-center based experience
Parameters | Patients with lung nodules(n = 50) | Patients without lung nodules(n = 39) | P value |
|---|---|---|---|
Age, median(IQR), years | 60(48–66) | 53(40–72) | 0.30 |
Men/women, n (%) | 3.55:1(39:11) | 2.25:1(27:12) | 0.35 |
Smoking history, n (%) | 29(58.0) | 13(33.3) | 0.02* |
Duration of disease, median(IQR), months | 7(3–12) | 5(2–13) | 0.60 |
Serum IgG4, median(IQR), mg/dl | 1185(426–2163) | 735(371–2130) | 0.48 |
Elevated ESR, n (%) | 20(40.0) | 9(23.1) | 0.09 |
Elevated CRP, n (%) | 9(18.0) | 9(23.1) | 0.55 |
Reduced C3, n (%) | 23(46.0) | 12(30.8) | 0.14 |
Reduced C4, n (%) | 16(32.0) | 7(17.9) | 0.13 |
Positive ANA, n (%) | 20(40.0) | 18(46.2) | 0.56 |
First symptoms, n (%) | |||
 Salivary gland swelling | 8(16.0) | 3(7.7) |  |
 Lymphadenopathy | 6(12.0) | 3(7.7) |  |
 Lacrimal gland swelling | 9(18.0) | 8(20.5) |  |
 Cough | 7(14.0) | 2(5.1) |  |
 Jaundice | 4(8.0) | 2(5.1) |  |
 Dysuria | 4(8.0) | 1(2.6) |  |
 Fever | 2(4.0) | 7(17.9) |  |
 Abdominal pain | 4(8.0) | 8(20.5) |  |
 Gum swelling | 1(2.0) | 0 |  |
 Low back pain | 2(2.0) | 0 |  |
 Edema | 3(6.0) | 3(7.7) |  |
 Fatigue | 0 | 1(2.6) |  |
 Diarrhea | 0 | 1(2.6) |  |
Number of extrapulmonary organs involved, median(IQR) | 2(1–3) | 2(1–3) | 0.14 |
Extrapulmonary organ involvement, n (%) | |||
 Salivary glands(submandibular gland and parotid gland) | 21(42.0) | 8(20.5) |  |
 Lymph node | 19(38.0) | 15(38.5) |  |
 Lacrimal gland | 14(28.0) | 8(20.5) |  |
 Pancreas | 15(30.0) | 10(25.6) |  |
 Kidney | 16(32.0) | 8(20.5) |  |
 Liver | 12(24.0) | 6(15.4) |  |
 Nasal sinus | 6(12.0) | 5(12.8) |  |
 Skin | 2(4.0) | 2(5.1) |  |
 Bile ducts | 4(8.0) | 9(23.1) |  |
 Peritoneum | 1(2.0) | 2(5.1) |  |
 Pituitary | 1(2.0) | 0 |  |
 Thyroid glands | 3(6.0) | 1(2.6) |  |
 Gingiva | 1(2.0) | 0 |  |
 Pericardium | 1(2.0) | 1(2.6) |  |
 Blood | 0 | 2(5.1) |  |