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Table 1 Demographic features of 17 participants in whom we measured serum prednisolone levels. (Proportions are reported as absolute values and percentages, and compared using a two-sample test of proportions, while point estimates are reported as medians with interquartile ranges, and compared using Wilcoxon’s test)

From: Serum prednisolone levels as a marker of oral corticosteroid adherence in severe asthma

Demographic Non-adherent
N = 3
Adherent
N = 14
p-value
Sex (M) 1 (33%) 7 (50%) 0.60
Age (years) 52 [46,66] 63.5 [50,70] 0.49
Prednisolone dose (mg/day) 10 [5, 25] 6.25 [5,10] 0.35
Inhaled Corticosteroid Dose (Fluticasone Propionate equivalents in mcg) 1500 [1000,2000] 1000 [1000,1500] 0.30
Number of medications prescribed for asthma 7 [4, 7] 7 [6, 8] 0.56
BMI (kg/m2) 27 [16,44] 31 [27,34] 0.61
Severe Exacerbations (/year) 6 [2,10] 4 [2,6] 0.67
ACQ-6 Score 2.3 [1.3,2.8] 2.4 [1.5,3.8] 0.75
FEV1 (% predicted) 104 [83,105] 69 [41,83] 0.06
FeNO (ppb) 30 [13,225] 19 [12,41] 0.45
Sputum eosinophils, % 1 [0.25,9.86] 1.25 [0,10.25] 0.80
Blood Eosinophils (cellsx109/L) 0.2 [0,0.5] 0.1 [0,0.116] 0.37
Cortisol level (μmol/L) (mean and 95% confidence interval) 155.2 (− 187,498) 33.0 (14.3, 51.7) 0.005
Self-reported Adherence 100% [71.4, 100] 100% [100,100] 0.03
Ex-smokers 1 (33%) 4 (29%) 0.87