Regional emphysema score is associated with tumor location and poor prognosis in completely resected NSCLC patients

Table 1 Characteristics of patients according to the emphysema score on CT (defined as a CT-based emphysema score of ≥3 of total 24)

Characteristic	Low (< 3) emphysema score (N = 312)	High (≥3) emphysema score (N = 145)	P value
Age	64.96 ± 9.07	69.86 ± 8.14	< 0.001
Male	167 (53.5)	126 (86.9)	< 0.001
ECOG PS			0.009
0–1	309 (99.0)	138 (95.2)
≥ 2	3 (1.0)	7 (4.8)
Smoking status			< 0.001
Never	146 (46.8)	18 (12.4)
Ever	166 (53.2)	127 (87.6)
Pathologic staging			0.001
I	203 (66.3)	78 (54.5)
II + III	103 (33.7)	65 (55.5)
Differentiation			0.002
Well + moderate	279 (89.4)	114 (78.6)
Poorly	33 (10.6)	31 (21.4)
Driver oncogene
EGFR mutation	69(30.3)	29 (29.0)	0.818
ALK translocation	8 (72.7)	3 (27.3)	0.760
COPD	71 (22.8)	89 (61.4)	< 0.001
FEV1/FVC	0.74 ± 0.09	0.65 ± 0.12	< 0.001
FEV1, % pred	96.36 ± 20.38	86.67 ± 21.41	< 0.001
Low DLCO (< 80)	91 (30.2)	69 (50.0)	< 0.001
DLCO	90.16 ± 19.04	79.67 ± 19.58	< 0.001
Pleural invasion	77 (25.2)	45 (31.7)	0.149
Lymphatic invasion	94 (30.4)	47 (32.6)	0.635
Vascular invasion	47 (15.2)	28 (19.4)	0.259
Extent of lung resection			0.405
Sublobar resection	35 (11.2)	20 (13.8)
Lobectomy	267 (85.6)	123 (84.8)
Pneumonectomy	10 (3.2)	2 (1.4)

Data are presented as mean ± standard deviation or number (%)
Abbreviations: EGFR epidermal growth factor receptor, ALK anaplastic lymphoma kinase, COPD chronic obstructive pulmonary disease, CT computed tomography, DLCO diffusing capacity of lung for carbon monoxide, ECOG PS Eastern Cooperative Oncology Group (ECOG) Performance Status, FEV1 Forced expiratory volume in 1 second, FVC forced vital capacity, pred predictive value

ISSN: 1471-2466