SNHG10 downregulated miR-21 in NSCLC cell through methylation. SNHG10 expression vector or miR-21 mimic was transfected into KLN 205 and HCC827 cells. Transfections were confirmed by RT-qPCR (a). The effects of SNHG10 overexpression on miR-21 (b), and the effects of miR-21 overexpression on SNHG10 (c) were also analyzed by RT-qPCR. MSP was performed to analyze the effects of SNHG10 overexpression on miR-21 (d). Mean ± SD values were presented and compared. M, methylation; U, un-methylation; *, p < 0.05.