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Table 3 Possible risk factors of sensitization (n = 93) and HLA mismatch (n = 53) among lung transplant recipients with/without PRA

From: The fraction of sensitization among lung transplant recipients in a transplant center in Japan

  Total (n = 93) PRA+ (n = 23) PRA- (n = 70) p-value
History of pregnant 24 (25.8%) 8 (34.8%) 16 (22.9%) 0.280
History of transfusion 84 (90.3%) 22 (95.7%) 62 (88.6%) 0.443
Prior transplanta 6 (6.5%) 0 (0.0%) 6 (8.6%) 0.331
Any episodes of acute rejection 13 (14.0%) 2 (8.7%) 11 (15.7%) 0.508
  Total (n = 53) PRA+ (n = 13) PRA- (n = 40) p-value
HLA mismatch A/B/DRb     0.796
mismatch 0–2 7 (13.2%) 1 (7.7%) 6 (15.0%)  
mismatch 3–4 23 (43.4%) 6 (46.2%) 17 (42.5%)  
mismatch 5–6 23 (43.4%) 6 (46.2%) 17 (42.5%)  
  1. Abbreviation: PRA panel-reactive assay, HLA human leukocyte antigen
  2. aincluding solid organ transplant and hematopoietic stem cell transplantation prior to lung transplantation
  3. bthe number of mismatched HLA-A/B/DR alleles (0–6) between donors and recipient in deceased-donor transplant and the total number of mismatch alleles (0–12) were divided to half in living-donor transplant