Table 2 The four SNPs associated with asthma
Genes | SNPs | Genetic models | Genotypes | Control n(%) | Case n(%) | P* | OR 95%CI* |
|---|---|---|---|---|---|---|---|
CDHR3 | rs3847076 | Dom | CC | 285 (68.2) | 185 (61.7) | 0.081 | 1.378 (0.962–1.973) |
CA + AA | 133 (31.8) | 115 (38.3) | |||||
Rec | CC + CA | 408 (97.6) | 285 (95.0) | 0.060 | 2.689 (0.958–7.545) | ||
AA | 10 (2.4) | 15 (5.0) | |||||
Add | CC/CA/AA | 0.032* | 1.407 (1.030–1.923)* | ||||
EMSY | rs2508746 | Dom | CC | 244 (58.4) | 197 (65.7) | 0.019* | 0.660 (0.465–0.935)* |
TC + TT | 174 (41.6) | 103 (34.3) | |||||
Rec | CC + TC | 396 (94.7) | 288 (96.0) | 0.445 | 0.733 (0.331–1.626) | ||
TT | 22 (5.3) | 12 (4.0) | |||||
Add | CC/TC/TT | 0.026* | 0.718 (0.536–0.961)* | ||||
EMSY | rs1892953 | Dom | AA | 115 (27.5) | 76 (25.3) | 0.647 | 1.094 (0.745–1.605) |
GA + GG | 303 (72.5) | 224 (74.7) | |||||
Rec | AA+GA | 319 (76.3) | 219 (73.0) | 0.015* | 1.667 (1.104–2.518)* | ||
GG | 99 (23.7) | 81 (27.0) | |||||
Add | AA/GA/GG | 0.081 | 1.240 (0.974–1.579) | ||||
EMSY | rs12278256 | Dom | GG | 357 (85.4) | 272 (90.7) | 0.033* | 0.563 (0.332–0.953)* |
TG + TT | 61 (14.6) | 28 (9.3) | |||||
Rec | GG + TG | 417 (99.8) | 300 (100) | 1 | – | ||
TT | 1 (0.2) | 0 (0) | |||||
Add | GG/TG/TT | 0.027* | 0.558 (0.332–0.937)* |