Skip to main content

Table 3 Results of stratification analysis based on gender, smoking status, BMI status, and onset age of asthma

From: Polymorphisms in the airway epithelium related genes CDHR3 and EMSY are associated with asthma susceptibility

SNPs

Genetic models

 

Stratified by gender

 

Stratified by smoking status

 

Stratified by BMI status

 

Stratified by onset age of asthma

P

OR 95%CI

P

OR 95%CI

P

OR 95%CI

P

OR 95%CI

rs3847076

Dom

male

0.048*

1.834 (1.005–3.347)

smoking

0.018*

2.252 (1.149–4.413)

BMI<24

0.004*

1.925 (1.233–3.007)

late onset asthma

0.063

1.428 (0.981–2.077)

Rec

0.115

5.656 (0.654–48.882)

0.09

4.222 (0.799–22.320)

0.12

2.835 (0.761–10.559)

0.049*

2.861 (1.006–8.134)

Add

0.023*

1.869 (1.091–3.202)

0.009*

2.168 (1.212–3.872)

0.005*

1.835 (1.234–2.726)

0.023*

1.457 (1.054–2.013)

rs2508746

Dom

female

non-smoking

0.014*

0.618 (0.420–0.908)

BMI<24

0.027*

0.612 (0.396–0.946)

late onset asthma

0.016*

0.637 (0.441–0.919)

Rec

0.498

0.737 (0.304–1.782)

0.862

0.920 (0.361–2.347)

0.419

0.706 (0.304–1.641)

Add

0.022*

0.685 (0.495–0.947)

0.06

0.710 (0.496–1.015)

0.021*

0.696 (0.511–0.948)

rs1892953

Dom

female

0.548

1.159 (0.717–1.873)

non-smoking

0.456

0.174 (0.770–1.790)

BMI<24

0.702

1.097 (0.682–1.766)

late onset asthma

0.692

1.084 (0.726–1.620)

Rec

0.038*

1.738 (1.031–2.927)

0.04*

1.615 (1.021–2.553)

0.017*

1.910 (1.123–3.250)

0.017*

1.680 (1.095–2.578)

Add

0.108

1.282 (0.947–1.737)

0.091

1.259 (0.964–1.644)

0.096

1.297 (0.955–1.761)

0.094

1.241 (0.964–1.599)

rs12278256

Dom

female

0.037*

0.468 (0.229–0.955)

non-smoking

0.023*

0.512 (0.287–0.913)

BMI<24

0.033*

0.485 (0.249–0.944)

late onset asthma

Rec

1

 

1

 

1

 

Add

0.032*

0.465 (0.231–0.936)

0.02*

0.508 (0.288–0.897)

0.028*

0.481 (0.250–0.923)

  1. *Adjusted for sex, age, body mass index and smoking history with logistic regression, P < 0.05
  2. Add additive model, Dom dominant model, Rec recessive model