Fig. 5

Biopsy specimens of oral nodules showed that a large amount of histiocytosis (some were foam cells) and neutrophil infiltration (the formation of a small abscess), with a small amount of eosinophils and lymphocytes infiltration in the subepithelial and salivary gland tissues without any caseous necrosis, obvious granulomatous lesions and neoplastic lesions. Immunohistochemical showed that CD163(+), CD68(+), CD45-LCA(+), S-100(+), CD35(+), SMA(−), desmin(−), HMB45(−), Melan-A(−), Cathepsin K(−), SOX10(−), CD21(−), CD23(−), Langerin(−), mutated Braf (V600E)(−), Eber(−), CyclinD1(+), Ki67(+). Biopsy specimens of esophageal nodules only found that numerous neutrophils and eosinophilic granulocyte infiltration