Table 3 Cox proportional hazards model analysis of variables affecting survival in NSCLC patients
From: CHCHD2 is a potential prognostic factor for NSCLC and is associated with HIF-1a expression
Variables | Categories | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
HR(95% CI) | P-value | HR(95% CI) | P-value | ||
Sex | Male/Female | 1.268 (0.885–1.816) | 0.196 | ||
Age (years) | <61/≥61 | 1.012 (0.734–1.395) | 0.940 | ||
Smoking history | Smoking/Non-smoking | 1.200 (0.864–1.665) | 0.277 | ||
Tumor position | Periphery type/Central type | 0.937 (0.670–1.309) | 0.702 | ||
Tumor size (cm) | ≤5/>5 | 1.511 (1.094–2.087) | 0.012 | 0.808 (0.561–1.164) | 0.252 |
Histological type | Adenocarcinoma/Squamous | 0.931 (0.671–1.291) | 0.669 | ||
Grade of differentiation | Well+moderate/poor | 1.814 (1.294–2.542) | 0.001 | 0.668 (0.468–0.952) | 0.026 |
TNM Stage | Ia~IIa/IIb~IIIb | 2.204 (1.592–3.052) | 0.000 | 1.076 (0.674–1.781) | 0.760 |
Lymph metastasis | Metastasis/Non-metastasis | 0.491 (0.351–0.688) | 0.000 | 1.661 (1.110–2.486) | 0.014 |
CHCHD2 expression | -~+/++~+++ | 2.966 (2.100–4.188) | 0.000 | 0.492 (0.321–0.752) | 0.001 |
HIF-1α expression | -~+/++~+++ | 2.866 (1.859–4.421) | 0.000 | 0.549 (0.338–0.891) | 0.015 |