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Table 3 Cox proportional hazards model analysis of variables affecting survival in NSCLC patients

From: CHCHD2 is a potential prognostic factor for NSCLC and is associated with HIF-1a expression

VariablesCategoriesUnivariate analysisMultivariate analysis
HR(95% CI)P-valueHR(95% CI)P-value
SexMale/Female1.268 (0.885–1.816)0.196  
Age (years)<61/≥611.012 (0.734–1.395)0.940  
Smoking historySmoking/Non-smoking1.200 (0.864–1.665)0.277  
Tumor positionPeriphery type/Central type0.937 (0.670–1.309)0.702  
Tumor size (cm)≤5/>51.511 (1.094–2.087)0.0120.808 (0.561–1.164)0.252
Histological typeAdenocarcinoma/Squamous0.931 (0.671–1.291)0.669  
Grade of differentiationWell+moderate/poor1.814 (1.294–2.542)0.0010.668 (0.468–0.952)0.026
TNM StageIa~IIa/IIb~IIIb2.204 (1.592–3.052)0.0001.076 (0.674–1.781)0.760
Lymph metastasisMetastasis/Non-metastasis0.491 (0.351–0.688)0.0001.661 (1.110–2.486)0.014
CHCHD2 expression-~+/++~+++2.966 (2.100–4.188)0.0000.492 (0.321–0.752)0.001
HIF-1α expression-~+/++~+++2.866 (1.859–4.421)0.0000.549 (0.338–0.891)0.015
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