Table 1 Demographics and clinical features, lung function parameters, and sleep-related findings of the study population
Variable | OSA | Controls | P-value |
|---|---|---|---|
(n = 55) | (n = 35) | ||
Age (years) | 54.9 ± 8.8 | 50.2 ± 5.4 | NS |
Gender, male sex | 39 (71) | 24 (68) | NS |
Smoking habit | |||
Smokers | 9 (16) | 0 (0) | |
Former smokers | 23 (42) | 0 (0) | |
No smokers | 23 (42) | 35 (100) | |
Pack/yr | 32.8 ± 24.6 | ||
BMI (Kg/m2) | 32.9 ± 6.7 | 28.3 ± 4.7 | < 0.01 |
Dyslipidemia (%) | 10 (18) | 0 (0) | |
Hypertension (%) | 14 (25) | 0 (0) | |
Diabetes (%) | 12 (22) | 0 (0) | |
Lung function parameters | |||
FVC (%pred.) | 85.4 ± 13.6 | 98 ± 12.5 | < 0.001 |
FEV1 (%pred.) | 87 ± 16.8 | 86 ± 13 | NS |
FEV1/FVC (%) | 102.7 ± 15.4 | 84 ± 9.5 | < 0.001 |
TLC (% pred) | 85 ± 5.9 | 86 ± 3.8 | NS |
DLCOsb(% pred) | 84.3 ± 16.1 | 86 ± 5 | NS |
pH | 7.38 ± 0.3 | 7.39 ± 0.4 | NS |
PaO2 (mmHg) | 84.7 ± 8.1 | 85.3 ± 6.2 | NS |
PaCO2 (mmHg) | 39.8 ± 4.1 | 38.6 ± 4.5 | NS |
Lactates (mmol/L) | 1.2 ± 1.4 | 1.1 ± 1.2 | NS |
HCO3− (mmol/L) | 26.1 ± 1.6 | 25.2 ± 1.4 | NS |
6MWT mt | 512.1 ± 175.1 | 568 ± 145.6 | NS |
Sleep-related events | |||
TST (minutes) | 358.4 ± 68.7 | 362 ± 64.5 | NS |
Supine time (%) | 49.7 ± 33.8 | 41.2 ± 29.8 | NS |
AHI | 46.3 ± 28.7 | 3.2 ± 1.2 | < 0.0001 |
Supine AHI (events/hour) | 41.4 ± 27 | 2.2 ± 2.4 | < 0.0001 |
ODI | 46 ± 30.7 | 3.3 ± 1.2 | < 0.0001 |
t90 (%) | 24 ± 22.2 | 0.4 ± 0.6 | 0.001 |
Nadir % SpO2 | 68.5 ± 11.5 | 83.2 ± 6.2 | 0.0001 |