Autoimmune pulmonary alveolar proteinosis developed during immunosuppressive treatment in polymyositis with interstitial lung disease: a case report

Table 1 Previously reported cases with autoimmune PAP complicated with CTDs

Case	Author	Age	Sex	Duration	Time to	CTD	CTD	GM-Ab	Regular	PAP
Case	Author	Age	Sex	Duration	onset	precedence	CTD	(μg/mL)	Treatment	Treatment
1 [5]	Nagasawa	26	F	month to year	2 M	Yes	SLE	10.6	PSL + IVCY	reduce PSL + discontinue IVCY
2 [6]	Yamasue	64	F		1.1Y	Yes	SSc	10.8	PSL + IVCY	reduce PSL + discontinue TAC
3 [7]	Imura	58	F		3.5Y	Yes	DM	1.8	PSL + CyA	reduce PSL
4 [8]	Ito	65	F	year to decade	5Y	Yes	RA	26.1	MTX + SASP	WLL + inhalation GM-CSF
5	Our case	52	F		15Y	Yes	PM	80.1	PSL	reduce PSL + WLL
6 [9]	Sakamoto	65	M		20Y	Yes	UC	62.8	SASP	WLL
7 [8]	Ito	68	F		26Y	Yes	RA	42.3	SASP	WLL + inhalation GM-CSF

CTD connective tissue disease, CyA cyclosporine A, DM dermatomyositis, GM-Ab granulocyte-macrophage colony-stimulating factor autoantibody, GM-CSF granulocyte-macrophage colony-stimulating factor, IVCY intravenous cyclophosphamide, MTX methotrexate, RA rheumatoid arthritis, SASP salazosulfapyridin, SLE systemic lupus erythematosus, SSc systemic sclerosis, TAC tacrolimus, UC ulcerative colitis, WLL whole lung lavage

ISSN: 1471-2466