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Table 2 Comparison of clinical features between IPA and CPA cases

From: Potential value of serum Aspergillus IgG antibody detection in the diagnosis of invasive and chronic pulmonary aspergillosis in non-agranulocytic patients

Characteristics

IPA (n = 37)

CPA (n = 21)

Overall (n = 58)

P

Ratio of male to female patients

23:14

13:8

36:22

0.985

Age, median years

64 (54.513, 72)

60 (46.524, 66)

64 (53.753, 70.248)

0.128

Course of disease (median, day)

17 (10, 30)

75 (23.251, 187.532)

20 (13, 60)

< 0.001

Microbiological findings

 Staphylococcus aureus

1 (2.703)

0

1 (1.724)

1.000

 Pseudomonas aeruginosa

1 (2.703)

1 (4.762)

2 (3.448)

1.000

 Candida albicans

1 (2.703)

1 (4.762)

2 (3.448)

1.000

 Acinstobacter baumannii

1 (2.703)

1 (4.762)

2 (3.448)

1.000

 Klebsiella pneumoniae

2 (5.405)

0

2 (3.448)

0.530

 Aspergillus

8 (21.622)

3 (14.286)

11 (18.966)

0.301

 Others

2 (5.405)

1 (4.762)

3 (5.172)

1.000

Clinical symptoms, n(%)

 Cough

34 (91.892)

18 (85.714)

52 (89.655)

0.657

 Fever (> 38 °C)

22 (59.459)

3 (14.286)

25 (43.103)

0.001

 Dyspnoea

25 (67.568)

8 (38.095)

33 (56.897)

0.029

 Haemoptysis

13 (35.135)

13 (61.905)

26 (44.828)

0.049

 Chest Pain

8 (21.622)

2 (9.524)

10 (17.241)

0.301

 Expectoration

33 (89.189)

17 (80.952)

50 (86.207)

0.443

Thoracic CT signs, n(%)

 Patchy exudate shadows

36 (97.297)

11 (52.381)

47 (81.034)

< 0.001

 Nodules

19 (51.351)

9 (42.857)

28 (48.276)

0.534

 segmental areas of consolidation

4 (10.811)

7 (33.333)

11(18.966)

0.077

 Cavity

17 (45.946)

14 (66.667)

31 (53.448)

0.128

 Pleural effusion

11 (29.730)

2 (9.524)

13 (22.414)

0.106

 Air crescent sign

2 (5.405)

9 (42.857)

11 (18.966)

0.001

 ground-glass attenuation

22 (59.459)

5 (23.810)

27 (46.552)

0.009

 other

1 (2.703)

13 (61.905)

14 (24.138)

< 0.001

Involving lobes of lung, n(%)

 Right upper lobe

28 (75.676)

13 (61.905)

41 (70.689)

0.268

 Right middle lobe

24 (64.865)

3 (14.286)

27 (46.552)

< 0.001

 Right lower lobe

30 (81.081)

9 (42.857)

39 (67.241)

0.003

 Left upper lobe

28 (75.676)

7 (33.333)

35 (60.345)

0.002

 Left lower lobe

27 (72.973)

12 (57.143)

39 (67.241)

0.217

Serum indexs

 Erythrocyte sedimentation rate (mm/h)

46 (26.515, 62)

30 (19.525, 55)

42 (25.514, 60.543)

0.369

 White blood cell count (109cells/L)

8.77 (5.534, 13.495)

6.97 (5.862, 8.471)

7.96 (5.788, 12.163)

0.212

 Neutrophil count (109cells/L)

7.3 (3.555, 11.205)

4.31 (3.475, 6.685)

5.31 (3.495, 9.945)

0.083

 Eosinophilia count (109cells/L)

0.07 (0.005, 0.135)

0.1 (0.035, 0.223)

0.085 (0.012, 0.153)

0.104

 Monocyte count (109cells/L)

0.45 (0.325, 0.57)

0.57 (0.385, 0.695)

0.49 (0.348, 0.603)

0.113

 Platelet ((109cells/L))

273 (199.5385.5)

257 (209,294.5)

263.5 (208.75, 336.25)

0.257

 Serum ALT level (U/L)

21.8 (15.65, 41.55)

20.2 (13.9, 30.4)

21.65 (15.425, 34.775)

0.32

 Serum creatinine level (μmol/L)

67 (53.75, 78.75)

67 (60, 77.5)

67 (59, 78)

0.715

 Serum albumin level (g/L)

36.2 (28.725, 41)

42.8 (39.5, 44.95)

40.4 (35.6, 43.9)

<0.001

 Serum LDH level (U/L)

262 (203, 373.5)

225 (187.5, 236.5)

233.5 (198, 326.75)

0.025

 Serum CRP level (mg/L)

4.09 (1.135, 11)

1.7 (0.485, 7.335)

2.85 (0.538, 8.615)

0.174

 PCT (ng/ml)

0.09 (0.050, 0.215)

0.05 (0.05, 0.063)

0.05 (0.05, 0.15)

0.007

 Lymphocyte count (109cells/L)

1.455 ± 0.63

1.890 ± 0.577

1.685 ± 0.639

< 0.001

  1. IPA invasive pulmonary aspergillosis, CPA chronic pulmonary aspergillosis, LDH lactate dehydrogenase, CRP C-reactive protein, PCT procalcitonin