The characteristics of the frequent exacerbator with chronic bronchitis phenotype and non-exacerbator phenotype in patients with chronic obstructive pulmonary disease: a meta-analysis and system review

Table 3 Difference of other indexes between the NE and FE-CB phenotypes

Secondary outcomes	included studies	MD	95% CI	P	I², P
the quantity of cigarettes smoked (pack-years)	Six studies	3.09	(1.60,4.58)	< 0.001	41%, 0.14
CAT score	Eight studies	5.61	(4.62,6.60)	< 0.001	80%, < 0.001
mMRC score	Four studies	0.72	(0.63,0.82)	< 0.001	57%, 0.07
BMI	Seven studies	-0.14	(−0.70,0.42)	0.62	75%, < 0.001
Charlson comorbidity index	Three studies	0.47	(0.37,0.58)	< 0.001	0, 0.70
BODEx	Three studies	1.78	(1.28,2.28)	< 0.001	91%, < 0.001

CI: confidence interval; CAT: COPD assessment test; BMI: body mass index; mMRC: modified British Medical Research Council dyspnea scale; BODEx: BMI, obstruction, dyspnea, exacerbations

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