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Table 1 Inclusion/Exclusion criteria

From: The effect of 50% oxygen on PtCO2 in patients with stable COPD, bronchiectasis, and neuromuscular disease or kyphoscoliosis: randomised cross-over trials

Study

Neuromuscular disease/ Kyphoscoliosis

Bronchiectasis

COPD

Inclusion criteria

 

Neuromuscular disease with ≥10% drop VC from sitting to lying or SNIP < 95% limitaand/or Kyphoscoliosis with an FVC < 65% predicted [18]b

Bronchiectasis as diagnosed by a doctor and confirmed with CT scan and/or Cystic fibrosis as diagnosed by a doctor

COPD, as diagnosed by a doctor

Exclusion criteriac

Study Baseline PtCO2

≥60 mmHg

≥60 mmHg

≥60 mmHg

Age

< 14 years old

< 14 years old

< 16 years old

Comorbidities

COPD

Morbid obesityd

COPD

Morbid obesityd

Bronchiectasis

Morbid obesityd

Spirometry

FEV1:FVC ratio ≤ 0.7, if participant is able to complete forced spirometry

 

FEV1:FVC ratio > 0.7 Inability to match FEV1 percentage predicted with a Bronchiectasis study participante

Other

 

Infection with Burkholderia > 10 pack year smoking history

 
  1. COPD Chronic Obstructive Pulmonary Disease, CT computerised tomography, FEV1 Forced expiratory volume in 1 s, FVC Forced vital capacity, PtCO2 Transcutaneous partial pressure of carbon dioxide, SNIP Sniff nasal inspiratory pressure, VC Vital capacity (slow)
  2. aFor examples of neuromuscular disease diagnoses see Benditt & Boitano, 2013 [19]. The SNIP limit is a value under which 95% of healthy subjects are as based on work by Uldry & Fitting [20].
  3. bNote that this may be calculated using arm span as per European Respiratory Society guidelines [21].
  4. cAll studies also excluded participants for any other condition which, at the investigator’s discretion, was believed may present a safety risk or impact the feasibility of the study or the study results
  5. dBody mass index (BMI) ≥ 40 kg/m2
  6. eTo be a match, the COPD participant must have an FEV1 percentage predicted within an absolute value of 5% of the FEV1 percentage predicted for the bronchiectasis study participant (values inclusive). An exception to this was for the three bronchiectasis participants that had FEV1 percentage predicted values of 109% or higher, who were matched with COPD participants with an FEV1 percent predicted of 80% or over (i.e. participants in the mildest COPD severity category based on FEV1) [22]. The exception was made as it was not feasible to recruit matching COPD participants with FEV1 values within 5% and the required obstruction (FEV1/FVC < 0.7), as this would require them to have an FVC well in excess of their predicted value
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BMC Pulmonary Medicine

ISSN: 1471-2466

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