Fig. 2

Histopathology of the lungs from mice with IPA on day 3 post-infection. Representative images of HE staining of lung tissue of a control mice, showing normal bronchioles and alveoli; b CTX-IPA mice showing diffuse pulmonary edema and congestion within alveolae; c PAS-stained lung sections of mice with CTX-IPA, showing invasion of bronchi, alveolae and blood vessels by numerous hyphae of A. fumigatus; d HE stain of lung tissue from HC-IPA mice showing destruction of bronchi, expansion of alveolar septa, increased macrophages aggregation and numerous inflammatory cells, especially neutrophils; e PAS-stained lung sections of mice with HC-IPA, showing a small mounts of hyphae in peribronchial areas; f HE stain of lung section of HC-IPA mice treated with PTX showing a small number of inflammatory cell in the lung septum, including neutrophils and lymphocytes. For a and f scale bars = 200 µm. For b–e scale bars = 100 µm