Therapeutic effects of pentoxifylline on invasive pulmonary aspergillosis in immunosuppressed mice

BMC Pulmonary Medicine

Table 2 Fungal burden of organs in mice infected with A. fumigatus

Group	Fungal burden of organs(mean log10 CFU/g ± SD)^a
Group	Lung	Brain	Kidneys
Control	None	None	None
Immunocompetent/exposed	None	None	None
CTX-IPA	4.19 ± 0.35*	2.35 ± 0.33	1.60 ± 0.69
HC-IPA	3.27 ± 0.41*	None	None

Mice were inoculated intranasally with 50 μL (1 × 10⁸ conidia/mL) of A. fumigatus spore suspension in IPA group and immunocompetent/exposed group. The groups of control received 50 μL of phosphate buffer saline (PBS). Tissue samples were collected from four mice per group on day 3 post-infection. Fungal burden in mice was measured 3 day after infection. Fungal burden was expressed as log10 CFU/g of tissue
^aCFU, colony-forming unit; SD, standard deviation; *p < 0.05, CTX-IPA group versus HC-IPA group

ISSN: 1471-2466