Therapeutic effects of pentoxifylline on invasive pulmonary aspergillosis in immunosuppressed mice

BMC Pulmonary Medicine

Table 3 Effect of PTX on pulmonary fungal burden

Group	Pulmonary fungal burden (mean log10 CFU/g ± SD)^a
Group	Day 1 post-infection	Day 3 post-infection	Day 5 post-infection
Immunocompetent/exposed	5.1 ± 0.43^c	None	None
CTX-IPA	6.18 ± 0.41^c	4.19 ± 0.35*	ND^b
CTX-IPA + PTX	5.61 ± 0.52	2.77 ± 1.06*	ND^b
HC-IPA	5.95 ± 0.65^c	3.27 ± 0.41	2.34 ± 0.24
HC-IPA + PTX	5.13 ± 1.30	None	None

Immunosuppressed mice, infected with A. fumigatus, were injected intraperitoneally with 20 mg/kg PTX daily for 5 days. Lung tissue samples from four mice per group were collected on days 1, 3, and 5 post-infection
^aCFU, colony-forming unit; SD, standard deviation
^bND, not detected
^cp < 0.05 compared with the immunocompetent/exposed group
*p < 0.05, CTX-IPA group vs. CTX-IPA + PTX group

ISSN: 1471-2466