Skip to main content
Fig. 6 | BMC Pulmonary Medicine

Fig. 6

From: SPAK-p38 MAPK signal pathway modulates claudin-18 and barrier function of alveolar epithelium after hyperoxic exposure

Fig. 6

The mechanisms of SPAK-p38 MAPK signal pathway modulating alveolar barrier function after hyperoxic exposure. Hyperoxia up-regulates p-SPAK and actives p-p38 by ROS, which mediates the decline in claudin-18 expression and disrupts the TJ of the alveolar epithelium. Down-regulation of SPAK inhibits p-p38 and restores the expression of claudin-18, which preserves barrier integrity of the alveolar epithelium. ROS reactive oxygen species, p-SPAK phosphorylated-SPAK, p-p38 phosphorylated-p38, TJ tight junction

Back to article page

BMC Pulmonary Medicine

ISSN: 1471-2466

Contact us