Table 1 The general characteristics of the patients included in this study
Characteristics | Control, n = 26 | ALI, n = 40 | p |
|---|---|---|---|
Age, years | 49.7 (31.8–67.7) | 65.6 (51.7–79.4) | 0.0002*** |
Sex, n (%) | |||
Male | 14 (53.8) | 28 (70.0) | |
Infection site, n (%) | |||
Blood | 3 (11.5) | 11 (27.5) | |
Lung | 10 (38.5) | 14 (35.0) | |
Abdomen | 4 (15.4) | 10 (25.0) | |
Other | 9 (34.6) | 5 (12.5) | |
Mortality, n (%) | 0 (0.0) | 12 (30.0) | |
Ventilator-free time, days | 3.1 (0.3–5.9) | 17.9 (1.9–34.0) | < 0.0001*** |
ICU stay time, days | 4.5 (3.0–6.8) | 15.5 (8.5–33.5) | < 0.0001*** |
APACHE II | 15.7 (7.7–23.6) | 22.5 (12.0–33.0) | 0.0069** |
SOFA | 6.0 (3.4–8.6) | 9.5 (6.0–13.1) | < 0.0001*** |
OI, mmHg | 374 (329–420) | 220 (170–270) | < 0.0001*** |
PEEP, cmH2O | 5.2 (4.7–5.7) | 7.0 (5.0–9.0) | < 0.0001*** |
Pplat, cmH2O | 18.0 (15.2–20.9) | 20.5 (16.0–25.0) | 0.0226* |
MAP, mmHg | 81.3 (74.3–88.2) | 84.3 (74.5–94.1) | 0.1835 |
HR, bpm | 94.2 (78.2–110.1) | 94.9 (74.2–115.5) | 0.8861 |
CVP, mmHg | 8.4 (6.9–10.0) | 9.8 (7.9–11.8) | 0.0063** |
NE, µg/kg/min | 0.19 (0.02–0.29) | 0.18 (0.08–0.38) | 0.0986 |
Lactate, mmol/L | 2.1 (0.8–3.4) | 2.2 (0.3–4.2) | 0.7388 |
mtDNA, log copies/µL | 4.13 (3.20–5.07) | 5.01 (3.38–6.64) | 0.0172* |
PCT, ng/mL | 7.0 (3.8–19.0) | 5.9 (2.0–20.3) | 0.4274 |
CRP, mg/L | 127 (79–175) | 125 (72–177) | 0.8537 |
IL-6, pg/mL | 139 (49–376) | 93 (28–145) | 0.8147 |
IL-8, pg/mL | 157 (42–274) | 131 (53–247) | 0.1971 |
IL-10, pg/mL | 12 (6–21) | 8 (5–14) | 0.2418 |
TNFα, pg/mL | 13 (9–19) | 21 (13–30) | 0.8210 |