Table 4 Laboratory data parameters in the different groups
Characteristics | Low mtDNA, n = 44 | High mtDNA, n = 22 | p |
|---|---|---|---|
Age, years | 57.1 (39.3–88.3) | 63.8 (48.5–79.2) | 0.1436 |
Sex, n (%) | |||
Male | 28 (63.6) | 13 (59.1) | |
Infection site | |||
Blood | 2 (4.5) | 12 (54.5) | |
Lung | 20 (45.5) | 4 (18.2) | |
Abdomen | 9 (20.5) | 5 (22.7) | |
Other | 13 (29.5) | 1 (4.6) | |
Mortality, n (%) | 1 (2.3) | 11 (50) | |
Ventilator-free time, days | 6.0 (1.8–6.7) | 22.3 (8.0–33.0) | < 0.0001*** |
ICU stay time, days | 6.0 (4.0–12.0) | 21.5 (11.3–42.8) | < 0.0001*** |
RV dysfunction | 7 (15.9) | 13 (59.1) | |
APACHE II | 15.2 (8.1–22.3) | 29.0 (20.0–38.0) | < 0.0001*** |
SOFA | 6.8 (3.8–9.7) | 10.9 (7.6–14.2) | < 0.0001*** |
OI, mmHg | 339 (255–422) | 222 (156–289) | 0.0002*** |
PEEP, cmH2O | 5.8 (4.6–7.0) | 7.4 (5.2–9.7) | 0.0005*** |
Pplat, cmH2O | 18.6 (15.2–22.0) | 21.5 (16.8–26.1) | 0.0080** |
MAP, mmHg | 83.4 (75.3–91.6) | 82.4 (72.2–92.7) | 0.6809 |
HR, bpm | 92.0 (76.2–107.8) | 99.7 (76.5–122.9) | 0.1216 |
CVP, mmHg | 8.4 (6.9–9.9) | 10.4 (8.8–12.0) | 0.0005*** |
NE, µg/kg/min | 0.17 (0–0.28) | 0.27 (0.15–0.87) | 0.0006*** |
Lactate, mmol/L | 1.8 (0.7–2.8) | 3.0 (0.6–5.4) | 0.0051** |
PCT, ng/mL | 6.0 (2.3–19.0) | 7.6 (2.5–52.5) | 0.0091** |
IL-6, pg/mL | 84 (36–271) | 130 (48–966) | 0.0280* |
IL-8, pg/mL | 131 (42–222) | 186 (58–458) | 0.0121* |
IL-10, pg/mL | 8 (5–15) | 12 (6–47) | 0.2038 |
TNFα, pg/mL | 15 (9–22) | 26 (18–36) | 0.5511 |