Table 1 Baseline demographics of the study population
Pilot phase | Validation phase | |||||||
|---|---|---|---|---|---|---|---|---|
SIL | DEW | CON | P value | SIL | DEW | CON | P value | |
N | 30 | 30 | 20 | 30 | 30 | 30 | ||
Male:Female | 25:5 | 27:3 | 14:6 | 0.148 | 27:3 | 27:3 | 24:6 | 0.095 |
Age (years) | 59.3 ± 10.1 | 63.0 ± 4.7 | 59.5 ± 9.9 | 0.182 | 56.2 ± 12.9 | 60.1 ± 7.9 | 55.1 ± 11.1 | 0.176 |
Smokers: non-smokers | 20:10 | 22:8 | 11:9 | 0.405 | 21:9 | 20:10 | 18:12 | 0.709 |
Current smokers:ex-smokers | 3:17 | 9:13 | 4:7 | 0.166 | 5:16 | 7:13 | 7:11 | 0.572 |
BMI (kg/m2) | 24.6 ± 3.2 | 23.7 ± 2.3 | 23.6 ± 2.12 | 0.345 | 22.8 ± 3.3 | 24.4 ± 3.3 | 23.8 ± 3.2 | 0.155 |
Duration of exposure (years) | 13.1 ± 7.2 | 9.3 ± 3.3 | NA | 0.002 | 11.8 ± 6.5 | 10.2 ± 5.0 | NA | 0.033 |
FVC (predicted %) | 77.6 ± 20.8 | 82.9 ± 22.3 | 83.2 ± 15.6 | 0.047 | 75.2 ± 23.3 | 80.4 ± 17.5 | 82.8 ± 17.4 | 0.039 |
FEV1 (predicted %) | 76.2 ± 19.7 | 79.6 ± 18.7 | 80.4 ± 12.1 | 0.216 | 77.7 ± 18.0 | 79.1 ± 19.6 | 80.7 ± 11.7 | 0.054 |
FEV1/FVC (%) | 81.1 ± 20.4 | 83.1 ± 24.6 | 82.8 ± 18.3 | 0.428 | 80.5 ± 19.4 | 82.0 ± 20.0 | 81.9 ± 14.2 | 0.366 |
DLCO (predicted %) | 76.7 ± 17.2 | 80.8 ± 18.4 | 81.2 ± 10.5 | 0.105 | 73.3 ± 15.4 | 79.4 ± 16.3 | 80.6 ± 11.1 | 0.233 |