Association between insulin resistance and lung function trajectory over 4 years in South Korea: community-based prospective cohort

Table 2 The effects of HOMA-IR on the lung function change

Exposure	Outcome: Annual lung function change
Exposure	∆ FEV1 (%-predicted/year)	∆ FVC (%-predicted/year)
Log transformed HOMA-IR	Beta (95% CI, P)	Beta (95% CI, P))
Per one unit increase (n = 4827)	− 0.23 (− 0.36 to − 0.11, < 0.001)	− 0.20 (− 0.33 to − 0.08, 0.001)

HOMA-IR quartile	Lowest quartile (Q1) of ∆ FEV1: < − 1.73%-predicted/year	P-trend	Lowest quartile (Q1) of ∆ FVC: < − 1.90%-predicted/year	P-trend
HOMA-IR quartile	Adjusted OR (95% CI, P)	P-trend	Adjusted OR (95% CI, P)	P-trend
1Q: < 1.05 (n = 1218)	1 (reference)	< 0.001	1 (reference)	< 0.001
2Q: 1.05–1.44 (n = 1211)	1.14 (0.94–1.39, 0.191)		1.15 (0.94–1.41, 0.162)
3Q: 1.45–2.02 (n = 1191)	1.22 (1.00–1.48, 0.055)		1.30 (1.06–1.59, 0.012)
4Q: ≥ 2.03 (n = 1207)	1.34 (1.09–1.66, 0.006)		1.38 (1.11–1.71, 0.004)

The rapid decline in lung function was defined in two aspects, which were the first quartile of FEV₁%-predicted and FVC %-predicted, respectively. ORs were adjusted for age, sex, college graduate, high income, smoking status, active physical activity, and annual averaged values of BMI, systolic and diastolic BP, waist circumference, fasting glucose, HbA1c, triglyceride, HDL cholesterol, eGFR, WBC count, hemoglobin, and CRP level. P-trend for HOMA-IR quartile was analyzed by Cochran-Armitage test for trend

ISSN: 1471-2466