Correlation between loss of Smad4 and clinical parameters of non-small cell lung cancer: an observational cohort study

Table 3 Correlation between serum Smad4 concentration and clinico-pathological parameters of NSCLC (N = 110)

Parameter	Group	Concentration of Smad4 in serum of NSCLC
		Value (ng/L)	Degree of freedom	Test of Homogeneity of Variances		95% CI for Mean	ANOVA
		Value (ng/L)	Degree of freedom	Statistical value	P value	95% CI for Mean	Statistical value	P value
Specimen source	Normal	166.67 ± 36.16	343	2.858	0.075	156.69–177.17	23.698	< 0.001
	Benign	151.66 ± 34.79				139.06–163.63
	Cancerous	109.41 ± 19.51^a				96.53–122.12
Gender	Male	136.34 ± 24.37	108	0.223	0.638	116.58–157.86	3.351	0.001
Gender	Female	99.21 ± 17.03				72.41–109.38
Ages	< 60	112.27 ± 16.47	108	0.358	0.127	98.68–128.39	1.367	0.313
Ages	≥ 60	107.56 ± 21.88				94.08–112.77
Smoking	No	118.43 ± 21.09	108	0.692	0.407	98.27–136.55	1.050	0.296
Smoking	Yes	102.36 ± 19.17				85.32–122.37
Histology	LSCC	123.59 ± 23.81	108	3.704	0.057	120.57–152.87	5.171	< 0.001
Histology	LAC	87 ± 18.62				65.21–94.24
Pathological grade	Poorly	78.65 ± 15.08^b	107	2.756	0.062	66.21–92.12	21.19	< 0.001
	Moderately	102.47 ± 19.18				78.36–117.89
	Well	155.82 ± 27.63				127.12–178.23
Lymphatic invasion	N0–N1	157.67 ± 26.65	108	0.107	0.744	126.41–177.89	5.057	< 0.001
Lymphatic invasion	N2–N3	88.24 ± 15.28				53.49–78.34
TNM	IA–IIB	138.43 ± 29.10	108	0.156	0.694	120.15–159.03	3.668	< 0.001
TNM	IIIA-IV	88.78 ± 13.22				71.33–107.97

M ± SD mean ± standard deviation, ANOVA analysis of variance, LAC lung adenocarcinoma, LSCC lung squamous cell carcinoma, TNM the TNM Classification of Malignant Tumours
^aP < 0.05, cancerous compared with benign and normal
^bP < 0.05, Poorly compared with moderately and well

ISSN: 1471-2466