Table 5 Logistc regression between serum Smad4 concentration and clinical parameters of NSCLC

Step 1^a

Gender

−.604

.711

.722

1

.396

.546

.135

2.204

Age

.030

.029

1.078

1

.299

1.031

.974

1.091

Smoking

.213

.584

.133

1

.715

1.238

.394

3.885

Histology

2.525

.806

9.818

1

.002

12.485

2.574

60.564

Differentiation

1.363

.401

11.530

1

.001

3.907

1.779

8.580

Lymphatic invasion

−.274

.757

.131

1

.717

.760

.172

3.351

TNM stage

− 1.414

.767

3.400

1

.065

.243

.054

1.093

Constant

− 4.330

2.096

4.268

1

.039

.013

Step 2^a

Gender

−.588

.710

.687

1

.407

.555

.138

2.233

Age

.029

.029

1.029

1

.310

1.030

.973

1.089

Smoking

.172

.569

.091

1

.763

1.188

.389

3.624

Differentiation

2.514

.805

9.763

1

.002

12.360

2.553

59.842

Lymphatic invasion

1.394

.393

12.579

1

.000

4.032

1.866

8.712

TNM stage

− 1.605

.558

8.270

1

.004

.201

.067

.600

Constant

− 4.218

2.059

4.198

1

.040

.015

Step 3^a

Gender

−.542

.689

.619

1

.431

.582

.151

2.244

Age

.028

.028

.954

1

.329

1.028

.972

1.087

Differentiation

2.491

.796

9.790

1

.002

12.073

2.536

57.471

Lymphatic invasion

1.364

.376

13.117

1

.000

3.910

1.869

8.178

TNM stage

− 1.608

.558

8.300

1

.004

.200

.067

.598

Constant

− 4.005

1.933

4.291

1

.038

.018

Step 4^a

Age

.033

.028

1.361

1

.243

1.033

.978

1.091

Differentiation

2.095

.601

12.131

1

.000

8.122

2.499

26.399

Lymphatic invasion

1.363

.372

13.400

1

.000

3.908

1.884

8.107

TNM stage

− 1.542

.546

7.966

1

.005

.214

.073

.624

Constant

− 4.381

1.895

5.344

1

.021

.013

Step 5^a

Differentiation

2.188

.592

13.638

1

.000

8.914

2.791

28.465

Lymphatic invasion

1.380

.372

13.754

1

.000

3.977

1.917

8.249

TNM stage

− 1.375

.512

7.203

1

.007

.253

.093

.690

Constant**

− 2.760

1.202

5.274

1

.022

.063