| |
Adjusteda
|
|---|
|
Mean difference or odds ratio (95% CI)
|
P value
|
|---|
|
Lung function
|
|
FEV%Pred
|
− 4.40
|
(− 6.78, − 2.03)
|
< 0.001
|
|
COPD (odds ratio)‡
|
1.42
|
(1.13, 1.78)
|
0.002
|
|
Quality of life/respiratory symptoms
|
|
CAT
|
0.70
|
(− 0.03, 1.43)
|
0.060
|
|
mMRC
|
0.10
|
(0.01, 0.20)
|
0.030
|
|
SGRQ total
|
3.30
|
(1.52, 5.10)
|
< 0.001
|
|
6-min walk distance (meters)
|
− 3.03
|
(− 13.7, 7.59)
|
0.576
|
|
Chest CT metric
|
|
% Emphysema (− 950)
|
1.22
|
(0.33, 2.12)
|
0.007
|
|
% air trapping (− 856)
|
3.23
|
(1.45, 5.01)
|
< 0.001
|
|
Exacerbations, last 12 months
|
|
Any (OR)b
|
1.24
|
(0.98, 1.58)
|
0.072
|
|
Severe (OR)b
|
1.52
|
(1.10, 2.10)
|
0.012
|
- Bold values indicate statistical significance at the p < 0.05 level
- aAdjusted for neighborhood poverty, clinical centers, age, sex, race, education, income, marital status, rural status, BMI, smoking status, and pack years
- bCoefficient represents odds ratio
