Table 3. Demographic and clinical characteristics of severely ill patients with COVID-19
| Â | Total (n = 744) | Non-progression (n = 622) | Progression (n = 122) | p-value |
|---|---|---|---|---|
Age (years) | 65 (56, 72) | 64 (56, 71.25) | 68.5 (62, 75) | 0.003 |
 ≥ 60 | 505 (67.9%) | 405 (65.1%) | 100 (82.0%) | <0.001 |
Gender | ||||
 Male | 396 (53.2%) | 319 (51.3%) | 77 (63.1%) | 0.017 |
 Female | 348 (46.8%) | 303 (48.7%) | 45 (36.9%) |  |
History of smoking | ||||
 Yes | 53/742 (7.1%) | 42 (6.8%) | 11/120 (9.2%) | 0.347 |
Clinical symptoms | ||||
 Cough | 544/743 (73.2%) | 453 (72.8%) | 91/121 (75.2%) | 0.589 |
 Fever | 558/743 (75.1%) | 469 (75.4%) | 89/121 (73.6%) | 0.667 |
 Asthma or dyspnea | 396/743 (53.3%) | 325 (52.3%) | 71/121 (58.7%) | 0.195 |
 Fatigue | 436/743 (58.7%) | 361 (58.0%) | 75/121 (62.0%) | 0.420 |
 Myalgia | 226/743 (30.4%) | 185 (29.7%) | 41/121 (33.9%) | 0.365 |
 Other features | 205/743 (27.6%) | 175 (28.1%) | 30/121 (24.8%) | 0.452 |
Number of symptoms | 3 (2, 4) | 3 (2, 5) | 4 (2, 4) | 0.068 |
 > 3 | 335/743 (45.1%) | 274 (44.1%) | 61/121 (50.4%) | 0.198 |
Maximum body temperature ≥ 37.3 ℃ | 314/719 (43.7%) | 227/613 (37.0%) | 87/106 (82.1%) | <0.001 |
Comorbidity | ||||
 Hypertension | 328/742 (44.2%) | 268 (43.1%) | 60/120 (50.0%) | 0.163 |
 Diabetes | 150/741 (20.2%) | 126/621 (20.3%) | 24/120 (19.2%) | 0.942 |
 Other cardiovascular disease | 143/741 (19.3%) | 111/621 (17.9%) | 32/120 (26.7%) | 0.026 |
 Respiratory disease | 89/743 (12.0%) | 50 (8.0%) | 39/121 (32.2%) | <0.001 |
 Other disease | 151/742 (20.4%) | 115/621 (18.5%) | 36/121 (29.8%) | 0.005 |
Imaging features | ||||
position | ||||
 Bilateral pulmonary | 652/671 (97.2%) | 573/591 (97.0%) | 79/80 (98.8%) | 0.364 |
Density | ||||
 mGGO | 518/653 (79.3%) | 463/578 (80.1%) | 55/75 (73.3%) | 0.173 |
Therapy | ||||
 Antibiotics | 327/737 (44.4%) | 233/619 (37.6%) | 94/118 (79.7%) | <0.001 |
 Antiviral | 432/736 (58.7%) | 349/618 (56.5%) | 83/118 (70.3%) | 0.005 |
 Corticosteroids | 186/737 (25.2%) | 117/617 (19.0%) | 69/120 (57.5%) | <0.001 |
 Traditional Chinese medicine treatment | 639/724 (88.3%) | 548/613 (89.4%) | 91/111 (82.0%) | 0.026 |
 Oxygen therapy | 613/737 (83.2%) | 499/618 (80.7%) | 114/119 (95.8%) | <0.001 |
 Other therapy | 203/733 (27.7%) | 128/615 (20.8%) | 75/118 (63.6%) | <0.001 |
Laboratory findings | ||||
 Leucocyte count, × 109 per L | 6.00 (4.80, 7.80) | 5.80 (4.73, 7.20) | 8.30 (5.70, 11.10) | <0.001 |
 Lymphocyte count, × 109 per L | 1.32 (0.89, 1.71) | 1.42 (0.98, 1.78) | 0.84 (0.51, 1.20) | <0.001 |
 Hemoglobin, g/L | 120 (109, 132) | 121 (110, 132) | 119 (102, 130) | 0.271 |
 Platelet count, × 109 per L | 224 (168, 274) | 225 (177, 271) | 216 (132, 292) | 0.156 |
 NLR | 2.85 (1.88, 5.25) | 2.59 (1.80, 3.94) | 7.74 (3.74, 17.11) | <0.001 |
 CRP, mg/L | 4.31 (1.39, 22.46) | 3.26 (1.15, 12.26) | 51.99 (11.70, 104.77) | <0.001 |
 ALT, U/L | 21.80 (14.80, 36.83) | 21.45 (14.63, 35.90) | 26.70 (15.38, 46.98) | 0.119 |
 Albumin, g/L | 36.40 (32.60, 39.30) | 37.00 (33.60, 39.60) | 32.70 (29.18, 36.03) | <0.001 |
 BUN, mmol/L | 4.59 (3.63, 6.12) | 4.44 (3.57, 5.68) | 6.34 (4.29, 9.08) | <0.001 |
 Creatinine, umol/L | 64.30 (54.30, 76.75) | 63.20 (53.50, 75.20) | 68.75 (56.70,89.58) | 0.002 |
 Creatine kinase, U/L | 45.91 (31.68, 70.43) | 45.60 (31.83, 66.65) | 48.20 (30.85, 98.60) | 0.596 |
 LDH, U/L | 200.10 (166.00, 258.60) | 192.10 (162.95, 237.05) | 296.25 (208.78, 430.08) | <0.001 |
 Prothrombin time, s | 12.97 (12.30, 13.90) | 12.86 (12.24, 13.68) | 14.10 (12.69, 15.45) | <0.001 |
 D-dimer, ug/L | 0.68 (0.33, 1.54) | 0.58 (0.31, 1.25) | 1.95 (0.81, 4.73) | <0.001 |