Table 2 Age-specific effectiveness and patients’ characteristics
Variable and category (reference) | 65 to < 70 years | 70 to < 75 years | ≥ 75 years | p value of interaction term with age category | |||
|---|---|---|---|---|---|---|---|
Case (n = 30) | Control (n = 974) | Case (n = 44) | Control (n = 1,085) | Case (n = 90) | Control (n = 1,995) | ||
PPSV23 (vs. absent) | 4 (13.3) | 94 (9.7) | 1 (2.3) | 97 (8.9) | 1 (1.1) | 123 (6.2) | 0.090 |
Crude odds ratio (95% CI) | 1.44 (0.49–4.22) | 0.24 (0.03–1.74) | 0.17 (0.02–1.24) | ||||
Adjusted odds ratioa (95% CI) | 1.34 (0.45–4.02) | 0.22 (0.03–1.59) | 0.17 (0.02–1.20) | 0.102 | |||
Male (vs. female) | 19 (63.3) | 585 (60.1) | 33 (75.0) | 696 (64.2) | 61 (67.8) | 1244 (62.4) | 0.736 |
Smoking (vs. non-smokers) | 0.727 | ||||||
Current smokers | 21 (70.0) | 522 (53.6) | 33 (75.0) | 578 (53.3) | 54 (60.0) | 968 (48.5) | |
Ex-smokers | 5 (16.7) | 215 (22.1) | 4 (9.1) | 222 (20.5) | 10 (11.1) | 351 (17.6) | |
Chronic respiratory diseases | |||||||
Asthma (vs. absent) | 5 (16.7) | 180 (18.5) | 11 (25.0) | 189 (17.4) | 14 (15.6) | 316 (15.8) | 0.506 |
COPD (vs. absent) | 6 (20.0) | 210 (21.6) | 16 (36.4) | 282 (26.0) | 20 (22.2) | 467 (23.4) | 0.360 |
Lung cancer (vs. absent) | 9 (30.0) | 415 (42.6) | 19 (43.2) | 409 (37.7) | 17 (18.9) | 770 (38.6) | 0.013 |
Interstitial pneumonia (vs. absent) | 7 (23.3) | 167 (17.2) | 8 (18.2) | 195 (18.0) | 14 (15.6) | 340 (17.0) | 0.646 |
NTM (vs. absent) | 11 (36.7) | 167 (17.2) | 10 (22.7) | 191 (17.6) | 27 (30.0) | 388 (19.5) | 0.405 |
Others chronic respiratory diseasesb (vs. absent) | 5 (16.7) | 87 (8.9) | 4 (9.1) | 118 (10.9) | 28 (31.1) | 332 (16.6) | 0.218 |
Diabetes (vs. absent) | 9 (30.0) | 253 (26.0) | 26 (59.1) | 350 (32.3) | 30 (33.3) | 606 (30.4) | 0.036 |
Chronic heart disease (vs. absent) | 12 (40.0) | 350 (35.9) | 25 (56.8) | 504 (46.5) | 58 (64.4) | 1036 (51.9) | 0.736 |
Chronic kidney disease (vs. absent) | 0 | 28 (2.9) | 3 (6.8) | 25 (2.3) | 0 | 64 (3.2) | 0.998 |
Systemic corticosteroid user (vs. absent) | 15 (50.0) | 311 (31.9) | 26 (59.1) | 363 (33.5) | 24 (26.7) | 515 (25.8) | 0.029 |