The polymorphisms of FGFR2 and MGAT5 affect the susceptibility to COPD in the Chinese people

BMC Pulmonary Medicine

Table 1 The primary information of SNPs in FGFR2 and MGAT5

SNP	Gene	Chr	Position	Allele A/B	Location	MAF		HWE p	OR (95% CI)	p	HaploReg
SNP	Gene	Chr	Position	Allele A/B	Location	Case	Control	HWE p	OR (95% CI)	p	HaploReg
rs2420915	FGFR2	10	122840277	A/G	Near	0.414	0.334	0.801	1.41 (1.12–1.77)	0.004	SiPhy cons, Enhancer histone marks, DNAse
rs1907240	FGFR2	10	122897959	G/A	Intron	0.423	0.387	0.905	1.16 (0.93–1.46)	0.190	SiPhy cons, Enhancer histone marks, DNAse, Motifs changed, Selected eQTL hits
rs2257129	FGFR2	10	122898697	T/C	Intron	0.414	0.387	0.722	1.12 (0.89–1.40)	0.344	Enhancer histone marks, Motifs changed
rs6430491	MGAT5	2	134840967	A/G	Near	0.351	0.438	0.909	0.69 (0.55–0.87)	0.002	Enhancer histone marks, Motifs changed, GRASP QTL hits
rs2593704	MGAT5	2	135005277	G/C	Intron	0.217	0.274	0.887	0.74 (0.57–0.95)	0.020	Promoter histone marks, Enhancer histone marks, DNAse, Proteins bound

SNP single nucleotide polymorphism, MAF minor allele frequency, HWE Hardy–Weinberg equilibrium, OR odds ratio, 95% CI 95% confidence interval
p values were calculated from χ² test
Bold values represent statistical significance (p < 0.05)

ISSN: 1471-2466