The polymorphisms of FGFR2 and MGAT5 affect the susceptibility to COPD in the Chinese people

Li, Xiaobo; Zhou, Guangyu; Tian, Xiaobo; Chen, Fei; Li, Guoyao; Ding, Yipeng

doi:10.1186/s12890-021-01498-3

BMC Pulmonary Medicine

Table 2 Associations of FGFR2 and MGAT5 genetic variants with COPD risk

From: The polymorphisms of FGFR2 and MGAT5 affect the susceptibility to COPD in the Chinese people

Gene	SNP	Model	Genotype	Frequency		Without adjustment		With adjustment
Gene	SNP	Model		Case	Control	OR (95% CI)	p^a	OR (95% CI)	p^b
FGFR2	rs2420915	Codominant	GG	0.326	0.446	1.00		1.00
			AA	0.153	0.115	1.83 (1.11–3.02)	0.018	1.85 (1.12–3.07)	0.016
			AG	0.521	0.439	1.62 (1.15–2.28)	0.006	1.62 (1.15–2.28)	0.006
		Dominant	GG	0.326	0.446	1.00		1.00
		Dominant	AA + AG	0.674	0.554	1.66 (1.20–2.30)	0.002	1.67 (1.20–2.31)	0.002
		Recessive	AG + GG	0.847	0.885	1.00		1.00
		Recessive	AA	0.153	0.115	1.40 (0.88–2.22)	0.156	1.42 (0.89–2.26)	0.139
		Additive	–	–	–	1.42 (1.12–1.80)	0.003	1.43 (1.13–1.81)	0.003
FGFR2	rs1907240	Codominant	AA	0.348	0.373	1.00		1.00
			GG	0.195	0.146	1.42 (0.90–2.26)	0.135	1.43 (0.90–2.27)	0.133
			GA	0.457	0.481	1.02 (0.72–1.44)	0.926	1.02 (0.72–1.45)	0.901
		Dominant	AA	0.348	0.373	1.00		1.00
		Dominant	GG + GA	0.652	0.627	1.11 (0.80–1.54)	0.525	1.12 (0.81–1.55)	0.507
		Recessive	GA + AA	0.805	0.854	1.00		1.00
		Recessive	GG	0.195	0.146	1.41 (0.93–2.15)	0.108	1.41 (0.93–2.15)	0.109
		Additive	–	–	–	1.16 (0.93–1.45)	0.196	1.16 (0.93–1.45)	0.190
FGFR2	rs2257129	Codominant	CC	0.342	0.370	1.00		1.00
			TT	0.169	0.145	1.27 (0.79–2.04)	0.332	1.27 (0.79–2.05)	0.329
			TC	0.489	0.486	1.09 (0.77–1.54)	0.629	1.10 (0.77–1.55)	0.607
		Dominant	CC	0.342	0.370	1.00		1.00
		Dominant	TT + TC	0.658	0.630	1.13 (0.81–1.57)	0.466	1.14 (0.82–1.58)	0.450
		Recessive	TC + CC	0.831	0.855	1.00		1.00
		Recessive	TT	0.169	0.145	1.21 (0.78–1.86)	0.398	1.20 (0.78–1.86)	0.402
		Additive	–			1.12 (0.89–1.40)	0.340	1.12 (0.89–1.41)	0.333
MGAT5	rs6430491	Codominant	GG	0.400	0.318	1.00		1.00
			AA	0.102	0.194	0.42 (0.25–0.69)	0.0006	0.41 (0.25–0.68)	0.0005
			AG	0.498	0.487	0.81 (0.58–1.15)	0.242	0.81 (0.58–1.15)	0.240
		Dominant	GG	0.400	0.318	1.00		1.00
		Dominant	AA + AG	0.600	0.682	0.70 (0.51–0.97)	0.033	0.70 (0.50–0.97)	0.033
		Recessive	AG + GG	0.898	0.806	1.00		1.00
		Recessive	AA	0.102	0.194	0.47 (0.30–0.74)	0.0012	0.47 (0.29–0.74)	0.0012
		Additive	–	–	–	0.68 (0.54–0.86)	0.0014	0.68 (0.54–0.86)	0.0013
MGAT5	rs2593704	Codominant	CC	0.619	0.529	1.00		1.00
			GG	0.054	0.077	0.60 (0.31–1.15)	0.121	0.61 (0.31–1.17)	0.136
			GC	0.327	0.394	0.71 (0.51–0.99)	0.045	0.72 (0.51–1.01)	0.057
		Dominant	CC	0.619	0.529	1.00		1.00
		Dominant	GG + GC	0.381	0.471	0.69 (0.50–0.95)	0.023	0.70 (0.51–0.97)	0.031
		Recessive	GC + CC	0.946	0.923	1.00		1.00
		Recessive	GG	0.054	0.077	0.68 (0.36–1.29)	0.239	0.69 (0.36–1.31)	0.258
		Additive	–	–	–	0.74 (0.57–0.96)	0.022	0.75 (0.58–0.97)	0.029

SNP single nucleotide polymorphism, OR odds ratio, 95% CI 95% confidence interval
p^a values were calculated by logistic regression analysis with the comparison between COPD patients and healthy controls
p^b values were calculated by logistic regression analysis with adjustment for age and gender
Bold values indicate statistical significance (p < 0.05)

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