Table 4 The relationship of FGFR2 and MGAT5 SNPs with COPD risk stratified by smoking
From: The polymorphisms of FGFR2 and MGAT5 affect the susceptibility to COPD in the Chinese people
Gene SNP | Model | Genotype | Smoking | No smoking | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
Frequency in case | Frequency in control | OR (95% CI) | p | Frequency in case | Frequency in control | OR(95% CI) | p | |||
FGFR2 rs2420915 | Allele | G | 0.613 | 0.615 | 1.00 | 0.567 | 0.674 | 1.00 | ||
A | 0.387 | 0.385 | 1.01 (0.64–1.60) | 0.966 | 0.433 | 0.326 | 1.58 (1.11–2.24) | 0.010 | ||
Codominant | GG | 0.370 | 0.385 | 1.00 | 0.291 | 0.458 | 1.00 | |||
AA | 0.144 | 0.154 | 1.07 (0.40–2.87) | 0.894 | 0.158 | 0.110 | 2.16 (0.99–4.68) | 0.052 | ||
AG | 0.486 | 0.461 | 1.11 (0.55–2.23) | 0.781 | 0.551 | 0.432 | 1.96 (1.16–3.29) | 0.012 | ||
Dominant | GG | 0.370 | 0.385 | 1.00 | 0.291 | 0.458 | 1.00 | |||
AA + AG | 0.630 | 0.615 | 1.10 (0.57–2.12) | 0.785 | 0.709 | 0.542 | 2.00 (1.21–3.28) | 0.006 | ||
Recessive | AG + GG | 0.856 | 0.846 | 1.00 | 0.842 | 0.890 | 1.00 | |||
AA | 0.144 | 0.154 | 1.01 (0.41–2.53) | 0.977 | 0.158 | 0.110 | 1.46 (0.72–3.00) | 0.297 | ||
Additive | – | – | – | 1.05 (0.66–1.68) | 0.836 | – | – | 1.60 (1.10–2.31) | 0.013 | |
FGFR2 rs1907240 | Allele | A | 0.617 | 0.577 | 1.00 | 0.542 | 0.640 | 1.00 | ||
G | 0.383 | 0.423 | 0.85 (0.54–1.33) | 0.470 | 0.458 | 0.360 | 1.50 (1.07–2.11) | 0.020 | ||
Codominant | AA | 0.407 | 0.327 | 1.00 | 0.301 | 0.381 | 1.00 | |||
GG | 0.172 | 0.173 | 0.92 (0.35–2.40) | 0.859 | 0.217 | 0.102 | 2.63 (1.22–5.68) | 0.014 | ||
GA | 0.421 | 0.500 | 0.68 (0.33–1.38) | 0.282 | 0.482 | 0.517 | 1.19 (0.70–2.01) | 0.525 | ||
Dominant | AA | 0.407 | 0.327 | 1.00 | 0.301 | 0.381 | 1.00 | |||
GG + GA | 0.593 | 0.673 | 0.73 (0.37–1.44) | 0.366 | 0.699 | 0.619 | 1.43 (0.86–2.35) | 0.165 | ||
Recessive | GA + AA | 0.828 | 0.827 | 1.00 | 0.783 | 0.898 | 1.00 | |||
GG | 0.172 | 0.173 | 1.14 (0.48–2.72) | 0.769 | 0.217 | 0.102 | 2.38 (1.17–4.81) | 0.016 | ||
Additive | – | – | – | 0.90 (0.58–1.41) | 0.645 | – | – | 1.51 (1.06–2.14) | 0.023 | |
FGFR2 rs2257129 | Allele | C | 0.627 | 0.577 | 1.00 | 0.552 | 0.640 | 1.00 | ||
T | 0.373 | 0.423 | 0.81 (0.52–1.28) | 0.371 | 0.448 | 0.360 | 1.45 (1.03–2.04) | 0.035 | ||
Codominant | CC | 0.390 | 0.327 | 1.00 | 0.303 | 0.381 | 1.00 | |||
TT | 0.137 | 0.173 | 0.75 (0.28–2.02) | 0.572 | 0.200 | 0.102 | 2.40 (1.11–5.23) | 0.027 | ||
TC | 0.473 | 0.500 | 0.79 (0.39–1.61) | 0.517 | 0.497 | 0.517 | 1.21 (0.72–2.05) | 0.468 | ||
Dominant | CC | 0.390 | 0.327 | 1.00 | 0.303 | 0.381 | 1.00 | |||
TT + TC | 0.610 | 0.673 | 0.78 (0.40–1.54) | 0.474 | 0.697 | 0.619 | 1.41 (0.86–2.33) | 0.177 | ||
Recessive | TC + CC | 0.863 | 0.827 | 1.00 | 0.800 | 0.898 | 1.00 | |||
TT | 0.137 | 0.173 | 0.86 (0.35–2.11) | 0.742 | 0.200 | 0.102 | 2.14 (1.05–4.36) | 0.036 | ||
Additive | – | – | – | 0.85 (0.53–1.36) | 0.499 | – | – | 1.46 (1.02–2.09) | 0.039 | |
MGAT5 rs6430491 | Allele | G | 0.588 | 0.606 | 1.00 | 0.699 | 0.576 | 1.00 | ||
A | 0.412 | 0.394 | 1.08 (0.68–1.70) | 0.757 | 0.301 | 0.424 | 0.59 (0.41–0.83) | 0.003 | ||
Codominant | GG | 0.333 | 0.365 | 1.00 | 0.452 | 0.364 | 1.00 | |||
AA | 0.156 | 0.154 | 1.11 (0.42–2.91) | 0.839 | 0.054 | 0.212 | 0.21 (0.09–0.49) | 0.0003 | ||
AG | 0.511 | 0.481 | 1.28 (0.63–2.62) | 0.495 | 0.494 | 0.424 | 0.92 (0.55–1.55) | 0.758 | ||
Dominant | GG | 0.333 | 0.365 | 1.00 | 0.452 | 0.364 | 1.00 | |||
AA + AG | 0.667 | 0.635 | 1.24 (0.63–2.42) | 0.537 | 0.548 | 0.636 | 0.69 (0.42–1.12) | 0.136 | ||
Recessive | AG + GG | 0.844 | 0.846 | 1.00 | 0.946 | 0.788 | 1.00 | |||
AA | 0.156 | 0.154 | 0.96 (0.40–2.32) | 0.927 | 0.054 | 0.212 | 0.22 (0.10–0.49) | 0.0002 | ||
Additive | – | – | – | 1.10 (0.68–1.76) | 0.704 | – | – | 0.58 (0.40–0.83) | 0.003 | |
MGAT5 rs2593704 | Allele | C | 0.789 | 0.635 | 1.00 | 0.777 | 0.770 | 1.00 | ||
G | 0.211 | 0.365 | 0.46 (0.29–0.76) | 0.002 | 0.223 | 0.230 | 0.96 (0.64–1.43) | 0.834 | ||
Codominant | CC | 0.639 | 0.404 | 1.00 | 0.602 | 0.609 | 1.00 | |||
GG | 0.061 | 0.135 | 0.37 (0.12–1.16) | 0.088 | 0.048 | 0.070 | 0.73 (0.26–2.04) | 0.544 | ||
GC | 0.300 | 0.461 | 0.42 (0.21–0.84) | 0.014 | 0.350 | 0.321 | 1.09 (0.65–1.82) | 0.756 | ||
Dominant | CC | 0.639 | 0.404 | 1.00 | 0.602 | 0.609 | 1.00 | |||
GG + GC | 0.361 | 0.596 | 0.41 (0.21–0.79) | 0.008 | 0.398 | 0.391 | 1.02 (0.63–1.67) | 0.930 | ||
Recessive | GC + CC | 0.939 | 0.865 | 1.00 | 0.952 | 0.930 | 1.00 | |||
GG | 0.061 | 0.135 | 0.54 (0.18–1.62) | 0.268 | 0.048 | 0.070 | 0.71 (0.26–1.95) | 0.501 | ||
Additive | – | – | – | 0.53 (0.32–0.87) | 0.012 | – | – | 0.96 (0.65–1.43) | 0.850 | |