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Table 3 Diagnostic performance of baseline FEF50% % predicted for different cut-off values, obtained by ROC analysis to predict methacholine responsiveness (PC20 < 16 mg/ml)

From: Baseline spirometry parameters as predictors of airway hyperreactivity in adults with suspected asthma

Cut-off (%) Sensitivity (%) Specificity (%) PPV (%) NPV (%)
FEF50% %predicted
  < 120 99.10 10 11.40 99
  < 115 97.80 14.50 11.80 98.30
  < 110 96.60 19.30 12.30 97.90
  1. Sensitivity, specificity, positive predictive value (PPV), negative predicted value (NPV)